Synthesis of 2,3-bis (halomethyl) quinoxaline derivatives and evaluation of their antibacterial and antifungal activities

Ishikawa, H.; Sugiyama, T.; Yokoyama, A.

Chemical and Pharmaceutical Bulletin 61(4): 438-444


ISSN/ISBN: 1347-5223
PMID: 23546003
DOI: 10.1248/cpb.c12-01061
Accession: 056074256

Download citation:  

Article/Abstract emailed within 0-6 h
Payments are secure & encrypted
Powered by Stripe
Powered by PayPal

Quinoxaline derivatives having bis(fluoromethyl), bis(chloromethyl), or bis(iodomethyl) groups at the 2- and 3-positions, and various electron-donating/withdrawing substituents at the 6- and/or 7-positions, were synthesized. Their antibacterial and antifungal activities were evaluated by means of minimum inhibitory concentration assays. The relationships between the substituents and the antimicrobial activities of the quinoxaline derivatives indicate that the electrophilicity of the halomethyl units plays an important role in generating the antimicrobial activity.