Synthesis of triazolothiazolidinone derivatives of coumarin with antimicrobial activity
Bhat, M.A.; Siddiqui, N.; Khan, S.A.; Mohamed, M.I.
Acta Poloniae Pharmaceutica 66(6): 625-632
2009
ISSN/ISBN: 0001-6837
PMID: 20050526
Accession: 056082747
A series of 2-(substituted phenyl)-3-[3-(2-oxo-2H-chromen-3-yl)-5-thioxo-1,5-dihydro-4H-1,2,4-triazol-4-yl]-1,3-thiazolidin-4-ones, 8a-n, were synthesized and evaluated for their antimicrobial activity. The structures of the compounds were confirmed on the basis of their elemental analysis and spectral data. Compounds 8k, 81 and 8m showed significant inhibition against S. aureus, compound 8m showed significant inhibition against E. coli and compounds 8b, 8e, 8i, 8j, 8k, 81 and 8m showed significant inhibition against C. albicans.