+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Systemic effect of Fructus Psoraleae extract on bone in mice

Systemic effect of Fructus Psoraleae extract on bone in mice

PhytoTherapy Research 24(10): 1578-1580

Fructus Psoraleae extract is used in China for the treatment of bone diseases. The objective of the study was to investigate the systemic effect of Fructus Psoraleae extract consumption on bone histomorphology. Sixteen 8-week-old male BALB/c mice were divided into control and experimental groups. In the control group, eight mice were fed daily with distilled water. In the experimental group, eight mice were fed daily with distilled water mixed with Fructus Psoraleae extract. The mice were kept for 5 weeks and then killed. Using micro-computed tomography, 20 micro-tomographic slices with a separation of 0.25 mm were acquired to cover the proximal end of the left tibia of each mouse. Quantitative morphometry of the bone structure was performed. The results showed that consumption of Fructus Psoraleae extract significantly increased the bone volume/tissue volume ratio by 11.8%. The bone trabeculae increased by 7.1% in thickness so that the bone density was increased. To conclude, Fructus Psoraleae extract taken orally increases bone density and alters bone histomorphology.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 056094893

Download citation: RISBibTeXText

PMID: 20564544

DOI: 10.1002/ptr.3184

Related references

General survey of Fructus Psoraleae from the different origins and chemical identification of the roasted from raw Fructus Psoraleae. Journal of Food and Drug Analysis 26(2): 807-814, 2018

Suppression of mast cell activity contributes to the osteoprotective effect of an herbal formula containing Herba Epimedii, Fructus Ligustri Lucidi and Fructus Psoraleae. Journal of Pharmacy and Pharmacology 66(3): 437-444, 2014

Multiorgan toxicity induced by EtOH extract of Fructus Psoraleae in Wistar rats. Phytomedicine 58: 152874, 2019

Evaluation of hepatotoxicity and cholestasis in rats treated with EtOH extract of Fructus Psoraleae. Journal of Ethnopharmacology 144(1): 73-81, 2013

Effects of fructus psoraleae extract on the intestinal absorption kinetics of geniposide and geniposidic acid in rat. Molecules 19(6): 7557-7567, 2015

Hepatotoxicity induced by psoralen and isopsoralen from Fructus Psoraleae: Wistar rats are more vulnerable than ICR mice. Food and Chemical Toxicology 2019, 2019

Inhibitive effects of Fructus Psoraleae extract on dopamine transporter and noradrenaline transporter. Journal of Ethnopharmacology 112(3): 498-506, 2007

Observations on effect of Fructus Psoraleae injection in 800 cases of psoriasis. Journal of Traditional Chinese Medicine 3(3): 229-230, 1983

The effects of an antiosteoporosis herbal formula containing epimedii herba, ligustri lucidi fructus and psoraleae fructus on density and structure of rat long bones under tail-suspension, and its mechanisms of action. PhytoTherapy Research 27(4): 484-492, 2013

Effect of Fructus Psoraleae on motility of gallbladder isolated smooth muscle strips from guinea pigs. World Journal of Gastroenterology 12(32): 5214-5218, 2006

Effect of the crude extract of Evodiae Fructus on the intestinal transit in mice. Planta Medica 60(4): 308-312, 1994

Anti-diarrheal effect of water extract of Evodiae fructus in mice. Journal of Ethnopharmacology 73(1/2): 39-45, 2000

Systemic effect of crude extract from rhizome of Drynaria fortunei on bone formation in mice. PhytoTherapy Research 20(4): 313-315, 2006

Protective effects of water fraction of Fructus Ligustri Lucidi extract against hypercalciuria and trabecular bone deterioration in experimentally type 1 diabetic mice. Journal of Ethnopharmacology 158 Pt A: 239-245, 2015

Effect of Psoraleae Fructus and Myristicae Semen in "Ershen pill" on serum metabonomics in spleen-kidney Yang deficiency diarrhea rats before and after processing. Zhongguo Zhong Yao Za Zhi 40(7): 1400-1403, 2015