+ Most Popular
Cunninghamia lanceolata plantations in China
Mammalian lairs in paleo ecological studies and palynology
Studies on technological possibilities in utilization of anhydrous milk fat for production of recombined butter-like products
Should right-sided fibroelastomas be operated upon?
Large esophageal lipoma
Apoptosis in the mammalian thymus during normal histogenesis and under various in vitro and in vivo experimental conditions
Poissons characoides nouveaux ou non signales de l'Ilha do Bananal, Bresil
Desensitizing efficacy of Colgate Sensitive Maximum Strength and Fresh Mint Sensodyne dentifrices
Administration of fluid by subcutaneous infusion: revival of a forgotten method
Tundra mosquito control - an impossible dream?
Schizophrenia for primary care providers: how to contribute to the care of a vulnerable patient population
Geochemical pattern analysis; method of describing the Southeastern limestone regional aquifer system
Incidence of low birth weights in a hospital of Mexico City
Graded management intensity of grassland systems for enhancing floristic diversity
Microbiology and biochemistry of cheese and fermented milk
The ember tetra: a new pygmy characid tetra from the Rio das Mortes, Brazil, Hyphessobrycon amandae sp. n. (Pisces, Characoidei)
Risk factors of contrast-induced nephropathy in patients after coronary artery intervention
Renovation of onsite domestic wastewater in a poorly drained soil
Observations of the propagation velocity and formation mechanism of burst fractures caused by gunshot
Systolic blood pressure in a population of infants in the first year of life: the Brompton study
Haematological studies in rats fed with metanil yellow
Studies on pasteurellosis. I. A new species of Pasteurella encountered in chronic fowl cholera
Dormancy breaking and germination of Acacia salicina Lindl. seeds
therapy of lupus nephritis. a two-year prospective study

TRPM channels in the vasculature

TRPM channels in the vasculature

Advances in Experimental Medicine and Biology 704: 707-729

ISSN/ISBN: 0065-2598

PMID: 21290323

DOI: 10.1007/978-94-007-0265-3_37

Recent studies show that mammalian melastatin TRPM nonselective cation channels (TRPM1-8), members of the largest and most diverse TRP subfamily, are widely expressed in the endothelium and vascular smooth muscles. When activated, these channels similarly to other TRPs permit the entry of sodium, calcium and magnesium, thus causing membrane depolarisation. Although membrane depolarisation reduces the driving force for calcium entry via TRPMs as well as other pathways for calcium entry, in smooth muscle myocytes expressing voltage-gated Ca(2+) channels the predominant functional effect is an increase in intracellular Ca(2+) concentration and myocyte contraction. This review focuses on several best documented aspects of vascular functions of TRPMs, including the role of TRPM2 in oxidant stress, regulation of endothelial permeability and cell death, the connection between TRPM4 and myogenic response, significance of TRPM7 for magnesium homeostasis, vessel injury and hypertension, and emerging evidence that the cold and menthol receptor TRPM8 is involved in the regulation of vascular tone.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 056107976

Download citation: RISBibTeXText

Related references

Profound defects in pupillary responses to light in TRPM-channel null mice: a role for TRPM channels in non-image-forming photoreception. European Journal of Neuroscience 35(1): 34-43, 2012

TRPM channels come into focus. Science 359(6372): 160-161, 2018

TRPM Channels in Human Diseases. Cells 9(12), 2020

Emerging roles of TRPM channels. Novartis Foundation Symposium 258: 248-258; Discussion: 258-266, 2004

On the Connections between TRPM Channels and SOCE. Cells 11(7), 2022

TRPM Family Channels in Cancer. Pharmaceuticals 11(2), 2018

The TRPM cation channels in the immune context. Current Pharmaceutical Design 11(21): 2765-2778, 2005

Function and pharmacology of TRPM cation channels. Naunyn-Schmiedeberg's Archives of Pharmacology 371(4): 307-314, 2005

The oncogenic roles of TRPM ion channels in cancer. Journal of Cellular Physiology 2019, 2019

A structural overview of the ion channels of the TRPM family. Cell Calcium 85: 102111, 2020

The role of TRPM channels in cell death. Pflugers Archiv: European Journal of Physiology 451(1): 235-242, 2005

TRPM channels and magnesium in early embryonic development. International Journal of Developmental Biology 59(7-9): 281-288, 2015

Emerging structural biology of TRPM subfamily channels. Cell Calcium 79: 75-79, 2019

TRPM channels: same ballpark, different players, and different rules in immunogenetics. Immunogenetics 63(12): 773-787, 2011

Functional TRPV and TRPM channels in human preadipocytes. Pflugers Archiv: European Journal of Physiology 466(5): 947-959, 2014