+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Temporal and spatial expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases following myocardial infarction



Temporal and spatial expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases following myocardial infarction



Cardiovascular Therapeutics 30(1): 31-41



Following a myocardial infarction (MI), the homeostatic balance between matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) is disrupted as part of the left ventricle (LV) response to injury. The full complement of responses to MI has been termed LV remodeling and includes changes in LV size, shape and function. The following events encompass the LV response to MI: (1) inflammation and LV wall thinning and dilation, (2) infarct expansion and necrotic myocyte resorption, (3) accumulation of fibroblasts and scar formation, and (4) endothelial cell activation and neovascularization. In this review, we will summarize MMP and TIMP roles during these events, focusing on the spatiotemporal localization and MMP and TIMP effects on cellular and tissue-level responses. We will review MMP and TIMP structure and function, and discuss specific MMP roles during both the acute and chronic phases post-MI, which may provide insight into novel therapeutic targets to limit adverse remodeling in the MI setting.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 056140557

Download citation: RISBibTeXText

PMID: 20645986

DOI: 10.1111/j.1755-5922.2010.00207.x


Related references

Differential release of matrix metalloproteinases and tissue inhibitors of matrix metalloproteinases in patients following alcohol induced myocardial infarction. Circulation 104(17 Suppl.): II 305, October 23, 2001

Discordant activation of gene promoters for matrix metalloproteinases and tissue inhibitors of the metalloproteinases following myocardial infarction. Journal of Surgical Research 172(1): 59-67, 2012

Relevance of matrix metalloproteinases and their inhibitors after myocardial infarction: a temporal and spatial window. Cardiovascular Research 69(3): 604-613, 2005

Temporal disparity in the induction of matrix metalloproteinases and tissue inhibitors of metalloproteinases after thoracic aortic aneurysm formation. Journal of Thoracic and Cardiovascular Surgery 132(4): 788-795, 2006

Temporal changes in tissue inhibitors of metalloproteinases (TIMPs)-1 and -2, and matrix metalloproteinases (MMPs)-2 and -9, during PGF2-induced luteolysis in sheep. 2001

Expression of matrix metalloproteinases-9 and tissue inhibitors of matrix metalloproteinases-1 in connective tissue of vaginal wall of women with stress urinary incontinence. Zhonghua Fu Chan Ke Za Zhi 41(12): 810-813, 2007

Lichong decoction reduces Matrix Metalloproteinases-2 expression but increases Tissue Inhibitors of Matrix Metalloproteinases-2 expression in a rat model of uterine leiomyoma. Journal of Traditional Chinese Medicine 36(4): 479-485, 2016

Imbalance of expression of matrix metalloproteinases (MMPs) and tissue inhibitors of the matrix metalloproteinases (TIMPs) in human pancreatic carcinoma. Journal of Pathology 182(3): 347-355, 1997

Effects of Tumor Necrosis Factor Alpha on the Expression of Matrix Metalloproteinases and Tissue Inhibitors of Matrix Metalloproteinases in Keratoconus Fibroblasts. Sheng Wu Yi Xue Gong Cheng Xue Za Zhi 33(6): 1139-1144, 2018

Expression of immunoreactive matrix metalloproteinases and tissue inhibitors of matrix metalloproteinases in human normal livers and primary liver tumors. Hepatology 23(6): 1341-1344, 1996

Temporospatial expression of matrix metalloproteinases and tissue inhibitors of matrix metalloproteinases in mouse antigen-induced arthritis. Histochemistry and Cell Biology 124(6): 535-545, 2005

Expression of matrix metalloproteinases, tissue inhibitors of metalloproteinases, and extracellular matrix mRNA following exposure to mineral fibers and cigarette smoke in vivo. Environmental Health Perspectives 105(Suppl. 5): 1247-1251, 1997

Upregulated expression of matrix metalloproteinases and tissue inhibitors of matrix metalloproteinases in BALB/c mouse brain challenged with Japanese encephalitis virus. Neuroimmunomodulation 19(4): 241-254, 2012

Expression of matrix metalloproteinases, tissue inhibitors of metalloproteinases, and extracellular matrix mRna following exposure to mineral fibers and cigarette smoke in vivo. Environmental Health Perspectives 105(Suppl 5): 1247-1251, 1997

Differential expression of tissue inhibitors of matrix metalloproteinases and matrix metalloproteinases in cells of B- and T-cell origin. Laboratory Investigation 68(1): 100A, 1993