+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Temporal summation of pressure pain during muscle hyperalgesia evoked by nerve growth factor and eccentric contractions

Temporal summation of pressure pain during muscle hyperalgesia evoked by nerve growth factor and eccentric contractions

European Journal of Pain 13(7): 704-710

Nerve growth factor (NGF) has a key role in the generation and potentiation of pain. Its centrally sensitizing effects may facilitate pain responses to noxious stimulus. This study assessed (1) the influence of NGF on delayed onset muscle soreness (DOMS) in shoulder muscles; and (2) the temporal summation of pressure pain during hyperalgesia induced by NGF and DOMS. In a blinded design, 10 healthy subjects were injected with NGF in the trapezius muscle on one side and with isotonic saline on the contralateral side as control. The subjects undertook shoulder eccentric exercise to induce DOMS in the shoulder muscles 3h after the injections. The soreness intensity to muscle contraction, pressure pain thresholds (PPT), and pain intensity to sequential stimuli (i.e. temporal summation at 1 and 30s inter-stimulus interval (ISI)) were assessed before injections - 3, 24h, and 4, 7, and 21 days after injections. The soreness intensity to muscle contraction significantly increased at 3 and 24h in both shoulders (P<0.05) and went back to baseline levels at day 7. The same development was seen in PPT as reduced thresholds (P<0.05). The NGF injected side had higher pain ratings during temporal summation at 1s ISI compared with the contralateral side 24h after injections. Intramuscular administration of NGF intensified the DOMS responses, evoking facilitated temporal summation. Central as well as peripheral sensitization mechanisms may play a role in the facilitation.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 056142697

Download citation: RISBibTeXText

PMID: 18710817

DOI: 10.1016/j.ejpain.2008.06.015

Related references

Repeated intramuscular injections of nerve growth factor induced parogressive muscle hyperalgesia, facilitated temporal summation and expanded pain areas. 2013

Repeated intramuscular injections of nerve growth factor induced progressive muscle hyperalgesia, facilitated temporal summation, and expanded pain areas. Pain 154(11): 2344-2352, 2013

Temporal summation of muscle pain evoked by very fast pressure sequences and rotation. Somatosensory and Motor Research 32(2): 99, 2015

Movement Evoked Pain and Mechanical Hyperalgesia after Intramuscular Injection of Nerve Growth Factor: A Model of Sustained Elbow Pain. Pain Medicine 16(11): 2180-2191, 2015

Spatial and temporal aspects of muscle hyperalgesia induced by nerve growth factor in humans. Experimental Brain Research 191(3): 371-382, 2008

Tissue characteristics during temporal summation of pressure-evoked pain. Experimental Brain Research 219(2): 255-265, 2012

Spatial and temporal summation of pain evoked by mechanical pressure stimulation. European Journal of Pain 13(6): 592-599, 2009

Pressure pain threshold mapping of the trapezius muscle reveals heterogeneity in the distribution of muscular hyperalgesia after eccentric exercise. European Journal of Pain 14(7): 705-712, 2010

Enhanced temporal summation of pressure pain in the trapezius muscle after delayed onset muscle soreness. Experimental Brain Research 170(2): 182-190, 2006

Young females with long-standing patellofemoral pain display impaired conditioned pain modulation, increased temporal summation of pain, and widespread hyperalgesia. Pain 159(12): 2530-2537, 2018

Experimental knee pain evoke spreading hyperalgesia and facilitated temporal summation of pain. Pain Medicine 14(6): 874-883, 2013

Age effects on pain thresholds, temporal summation and spatial summation of heat and pressure pain. Pain 115(3): 410-418, 2005

Preconditioning Contractions Suppress Muscle Pain Markers after Damaging Eccentric Contractions. Pain Research and Management 2018: 3080715, 2018

Hyperalgesia and temporal summation of pain after heat injury in man. Pain. 74(2-3): 189-197,., 1998

Insulin-like growth factor immunoreactivity increases in muscle after acute eccentric contractions. Journal of Applied Physiology 74(1): 410-414, 1993