+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

The ECM-cell interaction of cartilage extracellular matrix on chondrocytes



The ECM-cell interaction of cartilage extracellular matrix on chondrocytes



Biomed Research International 2014: 648459



Cartilage extracellular matrix (ECM) is composed primarily of the network type II collagen (COLII) and an interlocking mesh of fibrous proteins and proteoglycans (PGs), hyaluronic acid (HA), and chondroitin sulfate (CS). Articular cartilage ECM plays a crucial role in regulating chondrocyte metabolism and functions, such as organized cytoskeleton through integrin-mediated signaling via cell-matrix interaction. Cell signaling through integrins regulates several chondrocyte functions, including differentiation, metabolism, matrix remodeling, responses to mechanical stimulation, and cell survival. The major signaling pathways that regulate chondrogenesis have been identified as wnt signal, nitric oxide (NO) signal, protein kinase C (PKC), and retinoic acid (RA) signal. Integrins are a large family of molecules that are central regulators in multicellular biology. They orchestrate cell-cell and cell-matrix adhesive interactions from embryonic development to mature tissue function. In this review, we emphasize the signaling molecule effect and the biomechanics effect of cartilage ECM on chondrogenesis.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 056179363

Download citation: RISBibTeXText

PMID: 24959581

DOI: 10.1155/2014/648459


Related references

Interaction of chondrocytes, extracellular matrix and growth factors: relevance for articular cartilage tissue engineering. Osteoarthritis and Cartilage 10(8): 631-637, 2002

Cartilage oligomeric matrix protein and its binding partners in the cartilage extracellular matrix: interaction, regulation and role in chondrogenesis. Matrix Biology 37: 102-111, 2014

Homeostasis of the extracellular matrix by human chondrocytes obtained from normal cartilage. Clinical Rheumatology 20(5): 410, 2001

Extracellular matrix metabolism by chondrocytes. III. Modulation of proteoglycan synthesis by extracellular levels of proteoglycan in cartilage cells in culture. Biochimica et Biophysica Acta 500(1): 132-139, 1977

Interaction of chondrocytes with cartilage matrix macromolecules. Journal of Cell Biology 105(4 Part 2): 134A, 1987

Interleukin-17F affects cartilage matrix turnover by increasing the expression of collagenases and stromelysin-1 and by decreasing the expression of their inhibitors and extracellular matrix components in chondrocytes. Cytokine 56(2): 376-386, 2011

Homeostasis of the extracellular matrix of normal and osteoarthritic human articular cartilage chondrocytes in vitro. Osteoarthritis and Cartilage 11(11): 801-809, 2003

A phenomenological mixture model for biosynthesis and linking of cartilage extracellular matrix in scaffolds seeded with chondrocytes. Biomechanics and Modeling in Mechanobiology 10(6): 915-924, 2011

Transplantation of transduced chondrocytes protects articular cartilage from interleukin 1-induced extracellular matrix degradation. Journal of Clinical Investigation 96(5): 2454-2460, 1995

Poly(hydroxybutyrate-co-hydroxyhexanoate) promoted production of extracellular matrix of articular cartilage chondrocytes in vitro. Biomaterials 24(23): 4273-4281, 2003

The effect of agarose and dexamethasone on the nature and production of extracellular matrix components by elastic cartilage chondrocytes. Acta Biologica Hungarica 35(2-4): 245-258, 1984

Cell-derived polymer/extracellular matrix composite scaffolds for cartilage regeneration, Part 1: investigation of cocultures and seeding densities for improved extracellular matrix deposition. Tissue Engineering. Part C Methods 20(4): 340-357, 2014

In Vitro Expression of the Extracellular Matrix Components Aggrecan, Collagen Types I and II by Articular Cartilage-Derived Chondrocytes. Anatomia Histologia Embryologia 46(1): 43-50, 2017

Direct sectioning of unembedded cartilage: a simple method for microscopical and histochemical studies on chondrocytes and extracellular matrix. Zeitschrift für Mikroskopisch-Anatomische Forschung 104(3): 377-384, 1990

Pharmaceutical nanocarrier association with chondrocytes and cartilage explants: influence of surface modification and extracellular matrix depletion. Osteoarthritis and Cartilage 21(2): 377-384, 2013