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The PARP side of the nucleus: molecular actions, physiological outcomes, and clinical targets

The PARP side of the nucleus: molecular actions, physiological outcomes, and clinical targets

Molecular Cell 39(1): 8-24

The abundant nuclear enzyme PARP-1, a multifunctional regulator of chromatin structure, transcription, and genomic integrity, plays key roles in a wide variety of processes in the nucleus. Recent studies have begun to connect the molecular functions of PARP-1 to specific physiological and pathological outcomes, many of which can be altered by an expanding array of chemical inhibitors of PARP enzymatic activity.

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Accession: 056206111

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PMID: 20603072

DOI: 10.1016/j.molcel.2010.06.017

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