+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

The association between statin use and the diagnosis of prostate cancer in a population based cohort



The association between statin use and the diagnosis of prostate cancer in a population based cohort



Journal of Urology 184(2): 494-499



The effect of statin medication use on the risk of prostate cancer is unknown. We examined data from a longitudinal, population based cohort of 2,447 men between 40 and 79 years old who were followed from 1990 to 2007. Information on statin use was self-reported and obtained by biennial questionnaires. A randomly selected subset of men (634, 26%) completed biennial urological examinations that included serum prostate specific antigen measurements. Information on prostate biopsy and prostate cancer was obtained through review of community medical records. Of 634 statin users 38 (6%) were diagnosed with prostate cancer vs 186 (10%) of 1,813 nonstatin users. Statin use was associated with a decreased risk of undergoing prostate biopsy (HR 0.31; 95% CI 0.24, 0.40), receiving a prostate cancer diagnosis (HR 0.36; 95% CI 0.25, 0.53) and receiving a high grade (Gleason 7 or greater) prostate cancer diagnosis (HR 0.25; 95% CI 0.11, 0.58). Statin use was also associated with a nonsignificantly decreased risk of exceeding a prostate specific antigen threshold of 4.0 ng/ml (HR 0.63; 95% CI 0.35, 1.13). In addition, a longer duration of statin use was associated with a lower risk of these outcomes (all tests for trend p <0.05). Statin use is associated with a decreased risk of prostate cancer diagnosis. This association may be explained by decreased detection or cancer prevention.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 056244169

Download citation: RISBibTeXText

PMID: 20620405

DOI: 10.1016/j.juro.2010.03.149


Related references

Association Between Statin Use After Diagnosis of Esophageal Cancer and Survival: A Population-Based Cohort Study. Gastroenterology 150(4): 854-65.E1; Quiz E16-7, 2016

Statin use in relation to prostate cancer outcomes in a population-based patient cohort study. Prostate 73(11): 1214-1222, 2013

Statin Use Reduces Prostate Cancer All-Cause Mortality: A Nationwide Population-Based Cohort Study. Medicine 94(39): E1644, 2016

Statin use after diagnosis of breast cancer and survival: a population-based cohort study. Epidemiology 26(1): 68-78, 2015

Statin use after colorectal cancer diagnosis and survival: a population-based cohort study. Journal of Clinical Oncology 32(28): 3177-3183, 2014

Statin use after esophageal cancer diagnosis and survival: A population based cohort study. Cancer Epidemiology 48: 124-130, 2017

Statin and metformin therapy in prostate cancer patients with hyperlipidemia who underwent radiotherapy: a population-based cohort study. Cancer Management and Research 11: 1189-1197, 2019

Age-specific reference range of prostate-specific antigen and prostate cancer detection in population-based screening cohort in Japan: verification of Japanese Urological Association Guideline for prostate cancer. International Journal of Urology 21(11): 1120-1125, 2015

Pd03-04 Long-Term Rates Of Prostate Cancer Diagnosis And All-Cause Mortality In A Population-Based Cohort Of Men With An Initially Negative Prostate Biopsy. The Journal of Urology 197(4): e57-e58, 2017

The association between epididymo-orchitis and prostate cancer: A nationwide population-based cohort study. Medicine 98(21): E15363, 2019

Statin Use and Prostate Cancer Aggressiveness: Results from the Population-Based North Carolina-Louisiana Prostate Cancer Project. Cancer Epidemiology, Biomarkers and Prevention 25(4): 670-677, 2017

Age at diagnosis and prostate cancer treatment and prognosis: a population-based cohort study. Annals of Oncology 29(2): 377-385, 2017

Digoxin use after diagnosis of prostate cancer and survival: a population-based cohort study. Pharmacoepidemiology and Drug Safety 25(9): 1099-1103, 2017

The association of weight gain during adulthood with prostate cancer incidence and survival: a population-based cohort. International Journal of Cancer 129(5): 1199-1206, 2011

Survival in prostate carcinoma--outcomes from a prospective, population-based cohort of 8887 men with up to 15 years of follow-up: results from three countries in the population-based National Prostate Cancer Registry of Sweden. Cancer 103(5): 943-951, 2005