+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

The circadian clock gene Per1 suppresses cancer cell proliferation and tumor growth at specific times of day



The circadian clock gene Per1 suppresses cancer cell proliferation and tumor growth at specific times of day



Chronobiology International 26(7): 1323-1339



Cell cycle progression is tightly regulated. The expressions of cell cycle regulators, the products of which either promote or inhibit cell proliferation, oscillate during each cell cycle. Cellular proliferation and the expression of cell cycle regulators are also controlled by the circadian clock. Disruption of the circadian clock may thereby lead to deregulated cell proliferation. Mammalian Per2 is a core clock gene, the product of which suppresses cancer cell proliferation and tumor growth in vivo and in vitro. Because Per1, another key clock gene, is mutated in human breast cancers, and because its clock functions are similar and complementary to those of Per2, we have studied its role in modulating breast cancer cell proliferation and tumor growth. We find that breast cancer growth rate is gated by the circadian clock with two daily peaks and troughs, and that they are coupled to the daily expression patterns of clock-controlled genes that regulate cell proliferation. Down-regulation of the expression of tumor Per1 increases cancer cell growth in vitro and tumor growth in vivo by enhancing the circadian amplitude of the two daily tumor growth peaks. The data of the study suggest Per1 has tumor-suppressor function that diminishes cancer proliferation and tumor growth, but only at specific times of day.

(PDF emailed within 0-6 h: $19.90)

Accession: 056262511

Download citation: RISBibTeXText

PMID: 19916834

DOI: 10.3109/07420520903431301


Related references

Smad3 suppresses epithelial cell migration and proliferation via the clock gene Dec1, which negatively regulates the expression of clock genes Dec2 and Per1. American Journal of Pathology 2019, 2019

The clock gene PER1 suppresses expression of tumor-related genes in human oral squamous cell carcinoma. Oncotarget 7(15): 20574-20583, 2018

Effects and mechanism of the circadian clock gene Per1 on the proliferation, apoptosis, cycle, and tumorigenicity in vivo of human oral squamous cell carcinoma. Hua Xi Kou Qiang Yi Xue Za Zhi 34(3): 255-261, 2016

Abnormal expression of PER1 circadian-clock gene in oral squamous cell carcinoma. Oncotargets and Therapy 5(): 403-407, 2012

Correlated downregulation of estrogen receptor beta and the circadian clock gene Per1 in human colorectal cancer. Molecular Carcinogenesis 48(7): 642-647, 2009

Expression of the CLOCK, BMAL1, and PER1 circadian genes in human oral mucosa cells as dependent on CLOCK gene polymorphic variants. Doklady Biological Sciences 446: 323-326, 2013

Circadian Gene CLOCK Affects Drug-Resistant Gene Expression and Cell Proliferation in Ovarian Cancer SKOV3/DDP Cell Lines Through Autophagy. Cancer BioTherapy & Radiopharmaceuticals 32(4): 139-146, 2018

shRNA-mediated insulin-like growth factor I receptor gene silencing inhibits cell proliferation, induces cell apoptosis, and suppresses tumor growth in non-small cell lung cancer: in vitro and in vivo experiments. Zhonghua Yi Xue Za Zhi 87(21): 1506-1509, 2007

The circadian gene per1 plays an important role in cell growth and DNA damage control in human cancer cells. Molecular Cell 22(3): 375-382, 2006

Circadian gene Clock contributes to cell proliferation and migration of glioma and is directly regulated by tumor-suppressive miR-124. Febs Letters 587(15): 2455-2460, 2013

Effect of clock gene PER1 knockdown on clock gene networks in human oral squamous cell carcinoma. Hua Xi Kou Qiang Yi Xue Za Zhi 35(1): 57-62, 2017

Effect of phosphodiesterase type 4 on circadian clock gene Per1 transcription. Biochemical & Biophysical Research Communications 306(3): 781-785, July 4, 2003

The clock gene PER1 plays an important role in regulating the clock gene network in human oral squamous cell carcinoma cells. Oncotarget 7(43): 70290-70302, 2016

Tissue-specific and time-dependent regulation of the endothelin axis by the circadian clock protein Per1. Life Sciences 118(2): 255-262, 2015

The core clock gene Per1 phases molecular and electrical circadian rhythms in SCN neurons. Peerj 4: E2297-E2297, 2016