+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

The dark side of Toll-like receptor signaling: TLR9 activation limits the efficacy cancer radiotherapy



The dark side of Toll-like receptor signaling: TLR9 activation limits the efficacy cancer radiotherapy



Oncoimmunology 3: E27894



Radiation therapy is potentially immunogenic yet it rarely generates long-term antitumor effects. We have recently demonstrated that Toll-like receptor 9 (TLR9) jump-starts the signal transduction and activator of transcription 3 (STAT3)-dependent vascularization and regrowth of tumors that recur upon irradiation. We propose that the targeted inhibition of the TLR9/STAT3 signaling axis in myeloid cells can support the efficacy of local radiotherapy and prevent cancer recurrence.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 056280462

Download citation: RISBibTeXText

PMID: 25340001

DOI: 10.4161/onci.27894


Related references

Grancalcin (GCA) modulates Toll-like receptor 9 (TLR9) mediated signaling through its direct interaction with TLR9. European Journal of Immunology 46(3): 712-724, 2016

Toll-like receptor 2 (TLR2) and TLR9 signaling results in HIV-long terminal repeat trans-activation and HIV replication in HIV-1 transgenic mouse spleen cells: implications of simultaneous activation of TLRs on HIV replication. Journal of Immunology 170(10): 5159-5164, 2003

Cooperation of Toll-like receptor 2 and 6 for cellular activation by soluble tuberculosis factor and Borrelia burgdorferi outer surface protein A lipoprotein: role of Toll-interacting protein and IL-1 receptor signaling molecules in Toll-like receptor 2 signaling. Journal of Immunology 167(2): 987-994, 2001

Selectively targeting the toll-like receptor 9 (TLR9)--IRF 7 signaling pathway by polymer blend particles. Biomaterials 34(27): 6464-6472, 2014

Toll-Like Receptor 9 Alternatively Spliced Isoform Negatively Regulates TLR9 Signaling in Teleost Fish. Plos One 10(5): E0126388, 2016

Vaccination with plasmid DNA activates dendritic cells via Toll-like receptor 9 (TLR9) but functions in TLR9-deficient mice. Journal of Immunology 171(11): 5908-5912, 2003

The role of MAPK in Kupffer cell toll-like receptor (TLR) 2-, TLR4-, and TLR9-mediated signaling following trauma-hemorrhage. Journal of Cellular Physiology 210(3): 667-675, 2006

Activation of eosinophils via Toll-like receptor (TLR)3, TLR7 and TLR9: link between viral infection and asthma?. European Respiratory Review 17(107): 46-48, 2008

Role of atopic status in Toll-like receptor (TLR)7- and TLR9-mediated activation of human eosinophils. Journal of Leukocyte Biology 85(4): 719-727, 2009

Activation of NF-κB via endosomal Toll-like receptor 7 (TLR7) or TLR9 suppresses murine herpesvirus 68 reactivation. Journal of Virology 88(17): 10002-10012, 2014

Toll-like receptor TLR2 and TLR9 ligation triggers neutrophil activation in granulomatosis with polyangiitis. Rheumatology 52(7): 1183-1189, 2013

Toll/interleukin-1 receptor domain dimers as the platform for activation and enhanced inhibition of Toll-like receptor signaling. Journal of Biological Chemistry 287(37): 30993-31002, 2012

Toll-like receptor 9 (TLR9) agonists in the treatment of cancer. Oncogene 27(2): 161-167, 2008

Association study of Toll-like receptor 5 (TLR5) and Toll-like receptor 9 (TLR9) polymorphisms in systemic lupus erythematosus. Journal of Rheumatology 34(8): 1708-1711, 2007

Activation of toll-like receptor (TLR)2, TLR4, and TLR9 in the mammalian cornea induces MyD88-dependent corneal inflammation. Investigative Ophthalmology and Visual Science 46(2): 589-595, 2005