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The dark side of Toll-like receptor signaling: TLR9 activation limits the efficacy cancer radiotherapy

The dark side of Toll-like receptor signaling: TLR9 activation limits the efficacy cancer radiotherapy

Oncoimmunology 3: E27894

Radiation therapy is potentially immunogenic yet it rarely generates long-term antitumor effects. We have recently demonstrated that Toll-like receptor 9 (TLR9) jump-starts the signal transduction and activator of transcription 3 (STAT3)-dependent vascularization and regrowth of tumors that recur upon irradiation. We propose that the targeted inhibition of the TLR9/STAT3 signaling axis in myeloid cells can support the efficacy of local radiotherapy and prevent cancer recurrence.

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Accession: 056280462

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PMID: 25340001

DOI: 10.4161/onci.27894

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