+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

The effect of the "yellow" mutation at the mouse agouti locus on the hormonal profile of pregnancy and lactation



The effect of the "yellow" mutation at the mouse agouti locus on the hormonal profile of pregnancy and lactation



Rossiiskii Fiziologicheskii Zhurnal Imeni I.M. Sechenova 95(11): 1254-1257



The "yellow" mutation at the mouse agouti locus (A(y)/a-mice) results in obesity and type 2 diabetes. Maternal obesity in A(y)-mice impaired glucose tolerance in adult Agouti-negative offspring. Changes of hormone pattern during pregnancy and lactation are known to disregulate glucose metabolism in the adult progeny. The aim of the study was to assay blood levels of glucose, insulin, corticosterone and leptin during pregnancy (days 7, 13, 18) and lactation (days 1, 10, 21) in C57B1/6J mice of a/a (normal metabolism) and A(y)/a genotypes. A(y)/a-mice did not differ from a/a-mice in insulin and glucose levels during pregnancy and lactation, in corticosterone levels during pregnancy, but had higher leptin levels in pregnancy and lactation and increased corticosterone levels during lactation. A(y)/a-mice may be considered as a genetic model for studying impact of maternal leptin and corticosterone in developmental programming.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 056313245

Download citation: RISBibTeXText

PMID: 20058824


Related references

Pregnancy and lactation prevent melanocortin obesity syndrome in mice with Agouti yellow mutation. Doklady Biological Sciences 407: 163-165, 2006

Pregnancy and lactation suppress development of genetic obesity in female mice with Agouti yellow mutation. Rossiiskii Fiziologicheskii Zhurnal Imeni I.M. Sechenova 89(7): 906-908, 2003

Differential spontaneous transformation in vitro of newly established mouse fibroblast lines carrying or lacking the viable yellow mutation (Avy) of the mouse agouti locus. Molecular Carcinogenesis 15(1): 70-80, 1996

Hair pigment patterns in different integumental environments of the mouse influence of the agouti suppressor a s mutation on expression of agouti locus alleles. Journal of Heredity 71(4): 229-234, 1980

Effect of estradiol on food intake, glucose and fat metabolism in mice C57BL/6J with mutation yellow at the agouti locus. Rossiiskii Fiziologicheskii Zhurnal Imeni I.M. Sechenova 98(5): 636-645, 2012

Dermal epidermal interactions and the action of alleles at the agouti locus in the mouse 2. the viable yellow a v y and mottled agouti a m alleles. Developmental Biology 80(2): 495-500, 1980

A recessive allele of the mouse agouti locus showing lethality with yellow, Ay. Genetical Research 46(1): 95-99, 1985

Molecular basis of the pleiotropic phenotype of mice carrying the hypervariable yellow (Ahvy) mutation at the agouti locus. Genetics 142(2): 557-567, 1996

The agouti suppressor (As) coat color mutation in mice: developmental effects on the expression of agouti locus alleles. Journal of Experimental Zoology 220(1): 57-64, 1982

On association of the lethal yellow (A Y ) mutation in the agouti gene with the alterations in mouse brain and behavior. Behavioural Brain Research 359: 446-456, 2019

The influence of hyperleptinemia during pregnancy on fetal weight and obesity development in progeny mice with agouti yellow mutation. Rossiiskii Fiziologicheskii Zhurnal Imeni I.M. Sechenova 100(3): 370-379, 2014

Genetic instability at the agouti locus of the mouse (Mus musculus). I. Increased reverse mutation frequency to the Aw allele in A/a heterozygotes. Genetics 137(4): 1079-1087, 1994

Molecular analysis of the mouse agouti gene and the role of dominant agouti-locus mutations in obesity and insulin resistance. Molecular and genetic aspects of obesity 158, 1996

Cloning of the mouse agouti gene predicts a secreted protein ubiquitously expressed in mice carrying the lethal yellow mutation. Genes & Development 7(3): 454-467, 1993

Hypervariable yellow (Ahvy), a new murine agouti mutation: Ahvy displays the largest variation in coat color phenotypes of all known agouti alleles. Journal of Heredity 86(2): 121-128, 1995