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The effect of weight reduction on antioxidant enzymes and their association with dietary intake of vitamins A, C and E

Ramezanipour, M.; Jalali, M.; Sadrzade-Yeganeh, H.; Keshavarz, S.Ali.; Eshraghian, M.Reza.; Bagheri, M.; Emami, S.Seyed.

Arquivos Brasileiros de Endocrinologia E Metabologia 58(7): 744-749

2014


ISSN/ISBN: 0004-2730
PMID: 25372584
DOI: 10.1590/0004-2730000003206
Accession: 056314756

Our goal was to assess the effects of weight loss on antioxidant enzymes of red blood cells and it's relation with vitamins A, E and C intake in 30 obese women. General information, anthropometric measurements, 3-day food recall, and fasting blood samples were collected from 30 obese women at the beginning of the study and after 3 months intervention. Weight loss was set at about 10% of their weight before the intervention. Glutathione reductase and catalase activities showed a significant increase (P < 0.01) after weight reduction, but no significant changes were seen in the superoxide dismutase and glutathione peroxidase activities. There was a positive linear correlation between daily vitamin C intake with superoxide dismutase enzyme after intervention (P = 0.004, r = 0.507). There was a negative linear correlation between vitamin E intake and glutathione peroxidase activity before intervention (P = 0.005, r = -0.5). A negative correlation was found between daily vitamin A intake and glutathione reductase enzyme before and after intervention (r = -0.385, r = -0.397, P < 0.05) respectively. No significant correlation was observed between vitamins A, C, E amounts and catalase activity. Ten percent weight reduction can have a significant role in increasing antioxidant enzymes activities, especially glutathione reductase, and catalase enzymes in obese women. However, it is important to take into consideration a balanced amount of certain nutrients while administering a diet with limited energy.

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