+ Site Statistics
References:
52,654,530
Abstracts:
29,560,856
PMIDs:
28,072,755
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn

+ Translate
+ Recently Requested

The effects of exogenous glutathione on reduced glutathione level, glutathione peroxidase and glutathione reductase activities of rats with different ages and gender after whole-body Γ-irradiation



The effects of exogenous glutathione on reduced glutathione level, glutathione peroxidase and glutathione reductase activities of rats with different ages and gender after whole-body Γ-irradiation



Journal of the American Aging Association 26(3-4): 55-58



Age-and gender-related changes on reduced glutathione (GSH) level, glutathione peroxidase (GPx) and glutathione reductase (GR) activities in the liver of rat exposed to different dose of whole-body g-ray irradiation were determined. In addition, the effect of administration of exogenous GSH on endogenous GSH levels, GPx and GR activities was investigated. For this aim, male and female rats aged 1 and 5 moths were divided into two groups as g-ray and g-ray+GSH. Both groups were again divided into four groups as irradiated with 2, 4, 6 and 8 Gy doses. GSH level and GPx activity did not change with age while GR activity was decreased with age. Gender-dependent changes in GPx and GR activities were observed, but GSH values were not affect by sex. GSH levels, GPx and GR activities were not observed dose-associated changes of g-irradiation. GSH level and GPx activity in the 8Gy group were increased by GSH. GR activities of old male rats were found to be increased by glutathione in the 6 and 8Gy groups. These results indicate that radiation and administration of exogenous GSH affect gender-and age-dependent GSH level, GPx and GR activities in the rats.

(PDF emailed within 0-6 h: $19.90)

Accession: 056320247

Download citation: RISBibTeXText

PMID: 23604917

DOI: 10.1007/s11357-003-0005-8



Related references

Effects of taurine on glutathione peroxidase, glutathione reductase and reduced glutathione levels in rats. Pakistan Journal of Biological Sciences 14(3): 219-225, 2011

Effects of phenol compounds, glutathione analogues and a diuretic drug on glutathione S-transferase, glutathione reductase and glutathione peroxidase from canine erythrocytes. Comparative Biochemistry & Physiology B Comparative Biochemistry. 103(4): 863-867, 1992

Effect of selenium pre treatment on the tissue sulfhydryl groups glutathione reductase glutathione peroxidase and glutathione s transferase activities in rats intoxicated with cadmium. Korean Journal of Biochemistry 13(2): 180, 1981

Effect of common bile duct ligation on the liver glutathione s transferase glutathione peroxidase and glutathione reductase activities in ethanol intoxicated rats. Korean Biochemical Journal 23(2): 251-262, 1990

Effects of fluoroquinolones on activities of glutathione S-transferase, glutathione reductase and glutathione peroxidase in extrahepatic tissues. Zhongguo Kangshengsu Zazhi 30(7): 423-425,448, 2005

N-nitrosamines and their effects on the level glutathione, glutathione reductase and glutathione S-transferase activities in the liver of male mice. Cancer Letters 99(1): 29-34, 1996

Reduced glutathione, glutathione reductase, glutathione peroxidase, and pyruvate kinase in erythrocytes of human newborns and adults in Malaysia. British Journal of Haematology 25(5): 577-584, 1973

Determination of glutathione, glutathione reductase, glutathione peroxidase and glutathione S-transferase levels in human lung cancer tissues. Cancer Letters. 119(1): 13-19, 1997

Glutathione determination and a study of the activity of glutathione-peroxidase, glutathione-transferase, and glutathione-reductase in renal transplants. Renal Failure 24(4): 421-432, 2002

The influence of road transport on the activities of glutathione reductase, glutathione peroxidase, and glutathione-S-transferase in equine erythrocytes. Veterinary Clinical Pathology 41(1): 123-126, 2012

Glutathione peroxidase, glutathione S-transferase and glutathione reductase activities in normal and neoplastic human breast tissue. Cancer Letters 29(1): 37-42, 1985

Subcellular localization and modification with aging of glutathione glutathione peroxidase and glutathione reductase activities in human fibroblasts. Biochimica et Biophysica Acta 838(2): 211-220, 1985

Glutathione peroxidase, glutathione reductase and glutathione-S-transferase activities in the rhesus monkey lens as a function of age. Current Eye Research 5(3): 195-199, 1986

Glutathione peroxidase glutathione reductase and glutathione transferase activities in the human artery vein and heart. Journal of Molecular & Cellular Cardiology 22(9): 935-938, 1990

The effect of age and sex on glutathione reductase and glutathione peroxidase activities and on aerobic glutathione oxidation in rat liver homogenates. Biochemical Journal 112(1): 109-115, 1969