+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

The first US domestic report of disseminated Mycobacterium avium complex and anti-interferon-γ autoantibodies



The first US domestic report of disseminated Mycobacterium avium complex and anti-interferon-γ autoantibodies



Journal of Clinical Immunology 34(8): 928-932



Anti-interferon-γ (IFNγ) autoantibodies have been associated with disseminated mycobacterial infections, mostly in patients from Southeast Asia. We studied an American-born, Caucasian female with M. avium complex infection of the subglottic mucosa and brain for underlying etiologies of infection. Plasma was screened for anticytokine autoantibodies using a Luminex-based approach. The ability of patient plasma to block IFNγ-induced STAT1 phosphorylation in normal blood cells was evaluated by flow cytometry with intracellular staining. Plasma inhibition of IFNγ production and IFNγ-induced cytokines in normal and patient blood cells washed of autologous plasma was also evaluated. Patient plasma contained high-titer IgG anti-IFNγ autoantibodies, primarily of the IgG1 subclass. Patient but not control plasma prevented IFNγ-induced STAT1 phosphorylation and expression of the IFNγ-inducible cytokines tumor necrosis factor (TNF) α and interleukin (IL)-12 in normal blood cells. Patient blood cells washed free of autologous plasma demonstrated normal IFNγ production and response. Disseminated nontuberculous mycobacterial infections should always prompt immune evaluation. This first case of disseminated nontuberculous mycobacterial infection and anti-IFNγ autoantibodies in an American-born Caucasian suggests that anti-cytokine autoantibodies are not racially or regionally restricted.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 056344010

Download citation: RISBibTeXText

PMID: 25149293

DOI: 10.1007/s10875-014-0073-9


Related references

Recurrence of disseminated Mycobacterium avium complex disease in a patient with anti-gamma interferon autoantibodies by reinfection. Journal of Clinical Microbiology 53(4): 1436-1438, 2015

Late-Onset Disseminated Mycobacterium avium intracellulare Complex Infection (MAC), Cerebral Toxoplasmosis and Salmonella Sepsis in a German Caucasian Patient with Unusual Anti-Interferon-Gamma IgG1 Autoantibodies. Journal of Clinical Immunology 35(4): 361-365, 2015

Anti-interferon-gamma autoantibody in a patient with disseminated Mycobacterium avium complex. Journal of Infection and ChemoTherapy 15(2): 118-122, 2009

First report of hepatobiliary Mycobacterium avium infection developing obstructive jaundice in a patient with neutralizing anti-interferon-gamma autoantibodies. New Microbes and new Infections 27: 4-6, 2019

Disseminated Mycobacterium avium Infection Presenting with Bladder Lesions in a Patient with Interferon-γ-neutralizing Autoantibodies. Internal Medicine 57(20): 3041-3045, 2018

Disseminated Mycobacterium avium and recurrent Salmonella group D infection in a patient with autoantibodies to interferon-gamma. Southeast Asian Journal of Tropical Medicine and Public Health 44(3): 460-467, 2013

Adjunctive treatment of disseminated Mycobacterium avium complex infection with interferon alpha-2b in a patient with complete interferon-gamma receptor R1 deficiency. European Journal of Pediatrics 166(9): 981-985, 2007

Mycobacterium avium complex empyema in a patient with interferon gamma autoantibodies. Hawai'i Journal of Medicine and Public Health 73(9 Suppl 1): 15-17, 2014

Incidence of disseminated Mycobacterium avium-complex infection in HIV patients receiving antiretroviral therapy with use of Mycobacterium avium-complex prophylaxis. International Journal of Std and Aids 28(14): 1426-1432, 2017

Interferon gamma receptor deficiency in disseminated Mycobacterium avium complex infection. Journal of Investigative Medicine 45(3): 199A, 1997

Disseminated Mycobacterium avium complex infection in a patient carrying autoantibody to interferon-γ. Journal of Infection and ChemoTherapy 19(6): 1152-1157, 2013

Disseminated Mycobacterium avium complex infection in a patient with autoantibody to interferon-gamma. Internal Medicine 46(13): 1005-1009, 2007

Disseminated Talaromyces marneffei and Mycobacterium abscessus in a Patient With Anti-Interferon-γ Autoantibodies. Open Forum Infectious Diseases 3(2): Ofw093, 2016

Neutralizing antiinterferon-γ autoantibodies causing disseminated Mycobacterium avium complex infection in an HIV-infected patient on successful combination antiretroviral therapy. Aids 31(18): 2557-2559, 2017

IL-12-Independent costimulation pathways for interferon-gamma production in familial disseminated Mycobacterium avium complex infection. Clinical Immunology 91(2): 234-241, 1999