+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

The impact of exercise intensity on the release of cardiac biomarkers in marathon runners

The impact of exercise intensity on the release of cardiac biomarkers in marathon runners

European Journal of Applied Physiology 111(12): 2961-2967

We sought to determine the influence of exercise intensity on the release of cardiac troponin I (cTnI) and N-terminal pro-brain natriuretic peptide (NT-proBNP) in amateur marathon runners. Fourteen runners completed three exercise trials of the same duration but at exercise intensities corresponding to: (a) a competitive marathon [mean ± SD: heart rate 159 ± 7 beat min(-1), finish time 202 ± 14 min]; (b) 95% of individual anaerobic threshold [heart rate 144 ± 6 beat min(-1)] and; (c) 85% of individual anaerobic threshold [heart rate 129 ± 5 beat min(-1)]. cTnI and NT-proBNP were assayed from blood samples collected before, 30 min and 3 h post-exercise for each trial. cTnI and NT-proBNP were not different at baseline before each trial. After exercise at 85% of individual anaerobic threshold cTnI was not significantly elevated. Conversely, cTnI was elevated after exercise at 95% of individual anaerobic threshold (0.016 μg L(-1)) and to an even greater extent after exercise at competition intensity (0.054 μg L(-1)). Peak post-exercise values of NT-proBNP were elevated to a similar extent after all exercise trials (P < 0.05). The upper reference limit for cTnI (0.04 μg L(-1)) was exceeded in six subjects at competition intensity. No data for NT-proBNP surpassed its upper reference limit. Peak post-exercise values for cTnI and NT-proBNP were correlated with their respective baseline values. These data suggest exercise intensity influences the release of cTnI, but not NT-proBNP, and that competitive marathon running intensity is required for cTnI to be elevated over its upper reference limit.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 056366428

Download citation: RISBibTeXText

PMID: 21442162

DOI: 10.1007/s00421-011-1922-3

Related references

The impact of intermittent exercise in a hypoxic environment on redox status and cardiac troponin release in the serum of well-trained marathon runners. European Journal of Applied Physiology 116(10): 2045-2051, 2017

High-sensitivity cardiac troponin T release after a single bout of high-intensity interval exercise in experienced marathon runners. Journal of Exercise Science and Fitness 15(2): 49-54, 2018

The impact of exercise duration and intensity on the release of cardiac biomarkers. Scandinavian Journal of Medicine and Science in Sports 21(2): 244-249, 2011

Exercise-induced changes of left ventricular diastolic function in postmenopausal amateur marathon runners: assessment by echocardiography and cardiac biomarkers. European Journal of Preventive Cardiology 21(6): 782-790, 2015

Cardiac biomarkers, electrolytes, and other analytes in collapsed marathon runners: implications for the evaluation of runners following competition. American Journal of Clinical Pathology 129(6): 948-951, 2008

Impact of exercise intensity on cardiac function in adolescent runners. Journal of Sports Medicine and Physical Fitness 54(1): 93-99, 2014

High Sensitivity Troponin T in Marathon Runners, Marathon Runners with Heart Disease and Collapsed Marathon Runners. Scandinavian Journal of Medicine & Science in Sports 2019, 2019

Correlation of Cardiac Markers and Biomarkers With Blood Pressure of Middle-Aged Marathon Runners. Journal of Clinical Hypertension 17(11): 868-873, 2016

Changes in Cardiac Biomarkers Post-Marathon in Male and Female Runners Across the Age Spectrum: 3633 Board #72 June 4, 9: 30 AM - 11: 00 AM. Medicine and Science in Sports and Exercise 48(5 Suppl 1): 1009-1009, 2016

Cardiac Biomarkers Release in Preadolescent Athletes After an High Intensity Exercise. High Blood Pressure and Cardiovascular Prevention 25(1): 89-96, 2017

Cardiac troponin T release and inflammation demonstrated in marathon runners. Clinical Laboratory 56(1-2): 51-58, 2010

The influence of a half-marathon race upon cardiac troponin T release in adolescent runners. Current Medicinal Chemistry 18(23): 3452-3456, 2011

The Influence of a Half-Marathon Race Upon Cardiac Troponin T Release in Adolescent Runners. Current Medicinal Chemistry 18(23): 3452-3456, 2011

The impact of self-reported psychological stress levels on changes to peripheral blood immune biomarkers in recreational marathon runners during training and recovery. Neuroimmunomodulation 20(3): 164-176, 2013

Impact of marathon running on cardiac structure and function in recreational runners. Clinical Science 108(1): 73-80, 2004