+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

The impact of statin therapy on bone density changes in postmenopausal women

The impact of statin therapy on bone density changes in postmenopausal women

Vnitrni Lekarstvi 53(10): 1064-1070

Generalised use of statins in primary and secondary prevention of ischemic heart disease has led in recent years to the discovery ofa number of other "pleiotropic" effects ofstatins. One of them is the effect ofstatins on bone metabolism. The objective of the study was to monitor bone density, bone turnover markers and basic biochemical parameters in a group of postmenopausal women at regular intervals for a period of 2 years. The monitoring allowed for an assessment of the effect of statin therapy on those parameters. Statin therapy safety was also monitored. According to expectations, the group receiving active treatment recorded a decrease in the levels of total cholesterol, as well as LDL-cholesterol, and a mild decrease in the level of triacylglycerols. However, no significant difference in bone density in any of the measured regions (NECK, TROCH, SHAFT) was found when the trends in bone density parameters were compared for the two groups, nor there was a significant change in the respective T-scores. There was no significant difference with respect to the markers of bone formation or the markers of bone resorption between the group with active treatment and the control group. The results correspond to inconsistent data from the performed and quoted retrospective and prospective studies.

(PDF emailed within 1 workday: $29.90)

Accession: 056370719

Download citation: RISBibTeXText

PMID: 18072431

Related references

Statin use, clinical fracture, and bone density in postmenopausal women: Results from the women's health initiative observational study. Annals of Internal Medicine 139(2): 97-104, 15 July, 2003

Effects of hormone replacement therapy on bone mineral density in postmenopausal women with primary hyperparathyroidism: four-year follow-up and comparison with healthy postmenopausal women. Archives of Internal Medicine 160(14): 2161-2166, 2000

Additive impact of alfacalcidol on bone mineral density and bone strength in alendronate treated postmenopausal women with reduced bone mass. Journal of Musculoskeletal & Neuronal Interactions 11(1): 34-45, 2012

Bone density in postmenopausal women: high impact vs low impact exercise. Medicine and Science in Sports and Exercise 24(11): 1190-1194, 1992

Comparison of alveolar bone loss, alveolar bone density and second metacarpal bone density, salivary and gingival crevicular fluid interleukin-6 concentrations in healthy premenopausal and postmenopausal women on estrogen therapy. Journals of Gerontology. Series A, Biological Sciences and Medical Sciences 52(6): M343-M351, 1997

Additive effects of high-impact physical exercise and estrogen replacement therapy on calcaneal bone mineral density in postmenopausal women A randomized placebo-controlled study. Journal of Bone & Mineral Research 14(SUPPL 1): S185, Sept, 1999

The impact of subcutaneous oestradiol implants on biochemical markers of bone turnover and bone mineral density in postmenopausal women. Bjog 109(7): 812-820, 2002

Conjugated estrogen at a daily dose of 0625 mg and 03 mg had almost the same impact on the changes of bone mineral density and bone metabolism in postmenopausal women. Maturitas 27(SUPPL ): 119, 1997

Influence of bisphosphonate therapy on bone geometry, volumetric bone density and bone strength of femoral shaft in postmenopausal women with rheumatoid arthritis. Bmc Musculoskeletal Disorders 17(): 324-324, 2016

The impact of metabolic syndrome on bone mineral density in postmenopausal women. Gynecological Endocrinology 28(5): 391-395, 2012

Impact of smoking cessation on bone mineral density in postmenopausal women. Journal of Women's Health 15(10): 1141-1150, 2007

Changes in femoral bone mineral density associated with impact exercise in postmenopausal women. Journal of Physiology (Cambridge) 467(0): 313P, 1993

Effects of denosumab on bone mineral density and bone turnover in postmenopausal women transitioning from alendronate therapy. Journal of Bone and Mineral Research 25(1): 72-81, 2010

Study of the impact of candidate genes on bone mineral density in postmenopausal women. Zhonghua Fu Chan Ke Za Zhi 40(12): 803-807, 2006