+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

The multiple sclerosis-associated retrovirus and its HERV-W endogenous family: a biological interface between virology, genetics, and immunology in human physiology and disease

The multiple sclerosis-associated retrovirus and its HERV-W endogenous family: a biological interface between virology, genetics, and immunology in human physiology and disease

Journal of Neurovirology 15(1): 4-13

This mini-review summarizes current knowledge of MSRV (multiple sclerosis-associated retrovirus), founder member of the type W family of human endogenous retroviruses (HERVs), its pathogenic potential and association with diseases. As retrotransposable elements, HERVs behave differently from stable genes, and cannot be studied with "Mendelian genetics" concepts only. They also display complex interactions with other HERV families, and with classical viruses. These concepts may contribute to unravelling the etiopathogenesis of complex diseases such as multiple sclerosis, schizophrenia, and other chronic multifactorial diseases.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 056411828

Download citation: RISBibTeXText

PMID: 19039700

DOI: 10.1080/13550280802448451

Related references

Brains and peripheral blood mononuclear cells of multiple sclerosis (MS) patients hyperexpress MS-associated retrovirus/HERV-W endogenous retrovirus, but not Human herpesvirus 6. Journal of General Virology 88(Pt 1): 264-274, 2006

Human endogenous retrovirus HERV-Fc1 association with multiple sclerosis susceptibility: a meta-analysis. Plos One 9(3): E90182, 2015

Expression of HERV-Fc1, a human endogenous retrovirus, is increased in patients with active multiple sclerosis. Journal of Virology 86(7): 3713-3722, 2012

The etiology of multiple sclerosis: genetic evidence for the involvement of the human endogenous retrovirus HERV-Fc1. Plos One 6(2): E16652, 2011

MSRV/HERV-W/syncytin and its linkage to multiple sclerosis: the usability and the hazard of a human endogenous retrovirus. Journal of Neurovirology 11(2): 232-235, 2005

HERV-K(OLD): ancestor sequences of the human endogenous retrovirus family HERV-K(HML-2). Journal of Virology 75(19): 8917-8926, 2001

Human endogenous retrovirus (HERV)-W ENV and GAG proteins: physiological expression in human brain and pathophysiological modulation in multiple sclerosis lesions. Journal of Neurovirology 11(1): 23-33, 2005

Unreliable real-time PCR analysis of human endogenous retrovirus-W (HERV-W) RNA expression and DNA copy number in multiple sclerosis. Aids Research and Human Retroviruses 25(3): 377-8; Author Reply 379-81, 2009

Comprehensive analysis of human endogenous retrovirus group HERV-W locus transcription in multiple sclerosis brain lesions by high-throughput amplicon sequencing. Journal of Virology 87(24): 13837-13852, 2014

A general method for the identification of transcribed retrovirus sequences (R-U5 PCR) reveals the expression of the human endogenous retrovirus loci HERV-H and HERV-K in teratocarcinoma cells. Virology 192(2): 501-511, 1993

A human endogenous retrovirus-like (HERV) LTR formed more than 10 million years ago due to an insertion of HERV-H LTR into the 5' LTR of HERV-K is situated on human chromosomes 10, 19 and Y. Journal of General Virology 80: 835-839, 1999

Effects of interferon-beta therapy on elements in the antiviral immune response towards the human herpesviruses EBV, HSV, and VZV, and to the human endogenous retroviruses HERV-H and HERV-W in multiple sclerosis. Journal of Neuroimmunology 249(1-2): 105-108, 2012

The human endogenous retrovirus family HERV-K(HML-3). Genomics 80(3): 331-343, 2002

Human endogenous retrovirus type W (HERV-W) in schizophrenia: a new avenue of research at the gene-environment interface. World Journal of Biological Psychiatry 14(2): 80-90, 2013

HERV-K The biologically most active human endogenous retrovirus family. Journal of Acquired Immune Deficiency Syndromes & Human Retrovirology 10(2): 273, 1995