+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

The pathogenesis of murine coronavirus infection of the central nervous system

The pathogenesis of murine coronavirus infection of the central nervous system

Critical Reviews in Immunology 30(2): 119-130

Mouse hepatitis virus (MHV) is a positive-strand RNA virus that causes an acute encephalomyelitis that later resolves into a chronic fulminating demyelinating disease. Cytokine production, chemokine secretion, and immune cell infiltration into the central nervous system are critical to control viral replication during acute infection. Despite potent antiviral T-lymphocyte activity, sterile immunity is not achieved, and MHV chronically persists within oligodendrocytes. Continued infiltration and activation of the immune system, a result of the lingering viral antigen and RNA within oligodendrocytes, lead directly to the development of an immune-mediated demyelination that bears remarkable similarities, both clinically and histologically, to the human demyelinating disease multiple sclerosis. MHV offers a unique model system for studying host defense during acute viral infection and immune-mediated demyelination during chronic infection.

Please choose payment method:

(PDF emailed within 1 workday: $29.90)

Accession: 056428124

Download citation: RISBibTeXText

PMID: 20370625

Related references

Pathogenesis of murine coronavirus in the central nervous system. Journal of Neuroimmune Pharmacology 5(3): 336-354, 2010

The Biology of Persistent Infection: Inflammation and Demyelination following Murine Coronavirus Infection of the Central Nervous System. Current Immunology Reviews 5(4): 267-276, 2009

Priming of CD8+ T cells during central nervous system infection with a murine coronavirus is strain dependent. Journal of Virology 82(13): 6150-6160, 2008

Transcriptome profile within the mouse central nervous system and activation of myelin-reactive T cells following murine coronavirus infection. Journal of Neuroimmunology 162(1-2): 60-70, 2005

The pathogenesis of murine retroviral infection of the central nervous system. Brain Pathology 3(2): 123-128, 1993

Age-dependent pathogenesis of murine gammaherpesvirus 68 infection of the central nervous system. Molecules and Cells 27(1): 105-111, 2009

Persistence of jhm coronavirus in the murine central nervous system. Neurology 42(4 Suppl. 3): 438, 1992

Possible central nervous system infection by SARS coronavirus. Emerging Infectious Diseases 10(2): 342-344, 2004

Regional localization of virus in the central nervous system of mice persistently infected with murine coronavirus JHM. Virology 166(2): 328-338, 1988

The spike glycoprotein of murine coronavirus MHV-JHM mediates receptor-independent infection and spread in the central nervous systems of Ceacam1a-/- Mice. Journal of Virology 82(2): 755-763, 2008

A review of coronavirus infection in the central nervous system of cats and mice. Journal of Veterinary Internal Medicine 15(5): 438-444, September-October, 2001

Enhanced green fluorescent protein expression may be used to monitor murine coronavirus spread in vitro and in the mouse central nervous system. Journal of Neurovirology 8(5): 381-391, 2002

CCR1 deficiency increases susceptibility to fatal coronavirus infection of the central nervous system. Viral Immunology 20(4): 599-608, 2007

Role of CD25(+) CD4(+) T cells in acute and persistent coronavirus infection of the central nervous system. Virology 447(1-2): 112-120, 2013

Murine coronavirus spike glycoprotein mediates degree of viral spread, inflammation, and virus-induced immunopathology in the central nervous system. Virology 301(1): 9-20, 2002