+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

The prognostic role of the cancer stem cell marker aldehyde dehydrogenase 1 in head and neck squamous cell carcinomas: a meta-analysis



The prognostic role of the cancer stem cell marker aldehyde dehydrogenase 1 in head and neck squamous cell carcinomas: a meta-analysis



Oral Oncology 50(12): 1144-1148



This study aimed to investigate the correlation between aldehyde dehydrogenase 1 (ALDH1)-positive head and neck squamous cell carcinomas (HNSCC) and clinicopathological features and its effect on survival. A meta-analysis based on published studies was conducted to accurately evaluate the association between the presence of cancer stem cells (CSCs) in clinical samples and clinical outcome. A search in the PubMed, EMBASE, and Wanfang databases (up to May 1, 2014) was conducted. Publications assessing the clinical or prognostic significance of ALDH1 expression in HNSCC were identified and reviewed until May 1, 2014. A meta-analysis was performed to clarify the association between ALDH1 expression and clinical outcomes. A total of 9 publications satisfied the criteria and comprised 749 cases. ALDH1 expression was not significantly associated with tumor T stage [I+II vs. III+IV; odds ratio (OR)=1.23, 95% confidence interval (CI)=0.70-2.15, P=0.48]. However, in the identified studies, ALDH1 expression was highly correlated with tumor differentiation (G1+G2 vs. G3; OR=3.30, 95% CI=1.92-5.67, P<0.001), lymph node metastasis (OR=4.07, 95% CI=1.18-14.10, P=0.03), decreased overall survival [relative risk (RR)=1.84, 95% CI=1.43-2.36, P<0.0001], and decreased disease-free survival (RR=2.34, 95% CI=1.37-4.00, P=0.002). ALDH1-positive HNSCC patients had worse prognosis, which was associated with common clinicopathological features and poor prognostic factors.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 056446796

Download citation: RISBibTeXText

PMID: 25264224

DOI: 10.1016/j.oraloncology.2014.08.018


Related references

Single-marker identification of head and neck squamous cell carcinoma cancer stem cells with aldehyde dehydrogenase. Head and Neck 32(9): 1195-1201, 2010

Prognostic value of cancer stem cell marker aldehyde dehydrogenase in ovarian cancer: a meta-analysis. Plos one 8(11): E81050, 2013

Aldehyde dehydrogenase 1 isoenzyme expression as a marker of cancer stem cells correlates to histopathological features in head and neck cancer: A meta-analysis. Plos one 12(11): E0187615, 2017

Aldehyde dehydrogenase 1 is a putative marker for cancer stem cells in head and neck squamous cancer. Biochemical and Biophysical Research Communications 385(3): 307-313, 2009

Squamous cell carcinoma antigen as a prognostic marker and its correlation with clinicopathological features in head and neck squamous cell carcinoma: Systematic review and meta-analysis. Journal of Oral Pathology and Medicine 47(1): 3, 2018

Meta-analysis of the prognostic significance of perinodal spread in head and neck squamous cell carcinomas (HNSCC) patients. European Journal of Cancer 42(12): 1863-1868, 2006

Human papillomavirus as a favorable prognostic factor in a subset of head and neck squamous cell carcinomas: A meta-analysis. Journal of Medical Virology 89(4): 710-725, 2017

Role of cancer stem-cell marker doublecortin-like kinase 1 in head and neck squamous cell carcinoma. Oral Oncology 67: 109-118, 2017

Age determines the prognostic role of the cancer stem cell marker aldehyde dehydrogenase-1 in breast cancer. Bmc Cancer 12: 42, 2012

Expression of p16 as a prognostic marker in head and neck squamous cell carcinomas (HNSCC). Journal of Clinical Oncology 23(16_Suppl): 5520-5520, 2016

Aldehyde dehydrogenase activity is a cancer stem cell marker of tongue squamous cell carcinoma. Molecular Medicine Reports 5(4): 1116-1120, 2012

Prognostic Value of Drinking Status and Aldehyde Dehydrogenase 2 Polymorphism in Patients With Head and Neck Squamous Cell Carcinoma. Journal of Epidemiology 26(6): 292-299, 2016

The prognostic impact of cancer stem-like cell biomarker aldehyde dehydrogenase-1 (ALDH1) in ovarian cancer: A meta-analysis. Gynecologic Oncology 150(1): 151-157, 2018

Image cytometry of cyclin D1: a prognostic marker for head and neck squamous cell carcinomas. Cancer Epidemiology, Biomarkers & Prevention 10(5): 455-459, 2001

Identification of osteopontin as a prognostic plasma marker for head and neck squamous cell carcinomas. Clinical Cancer Research 9(1): 59-67, 2003