+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

The role of activated protein C in cancer progression



The role of activated protein C in cancer progression



Thrombosis Research 125(Suppl. 2): S138-S142



Activated protein C (APC) is best known as a natural anticoagulant that also has direct cell signaling properties which (among others) enhance vascular barrier function. We recently established the relevance of APC-induced barrier enhancement by showing that endogenous APC limits cancer cell extravasation. In line with this concept, repeated administration of exogenous APC reduced the number of experimental metastasis. It is thus tempting to speculate that exogenous APC administration would be a novel therapeutic avenue to fight cancer metastasis. The current review summarizes recent data on the role of the protein C pathway in cancer metastasis. It discusses the APC pathway as a potential novel target to influence cancer progression, but it also points to several limitations of APC administration in the setting of cancer cell metastasis.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 056472042

Download citation: RISBibTeXText

PMID: 20433994

DOI: 10.1016/s0049-3848(10)70032-3


Related references

Role of p-21-activated kinases in cancer progression. International Review of Cell and Molecular Biology 309: 347-387, 2014

Activated mitogen-activated protein kinase expression during human breast tumorigenesis and breast cancer progression. Clinical Cancer Research 8(6): 1747-1753, 2002

Tumour progression and cancer-induced pain: a role for protease-activated receptor-2?. International Journal of Biochemistry and Cell Biology 57: 149-156, 2014

Activation of mitogen-activated protein kinase associated with prostate cancer progression. Cancer Research 59(2): 279-284, 1999

Metformin prevents progression of heart failure in dogs: role of AMP-activated protein kinase. Circulation 119(19): 2568-2577, 2009

The role of peroxisome proliferator-activated receptor gamma in bladder cancer in relation to angiogenesis and progression. General Pharmacology 35(5): 269-275, 2000

Mitogen-activated protein kinase phosphatase-1 is involved in the progression of epithelial ovarian cancer. Proceedings of the American Association for Cancer Research Annual Meeting 40: 372, 1999

Energy metabolic alterations in the progression of atrial fibrillation: Potential role of AMP-activated protein kinase as a critical regulator. International Journal of Cardiology 212: 14-15, 2016

The overexpression of RHAMM, a hyaluronan-binding protein that regulates ras signaling, correlates with overexpression of mitogen-activated protein kinase and is a significant parameter in breast cancer progression. Clinical Cancer Research 4(3): 567-576, 1998

Constitutive activation of the 41- and 43-kDa mitogen-activated protein (MAP) kinases in the progression of prostate cancer to an androgen-independent state. International Journal of Urology 12(10): 899-905, 2005

Crosstalk between estrogen receptor and mitogen-activated protein kinase signaling in the development and progression of endometrial cancer. International Journal of Gynecological Cancer 21(8): 1357-1365, 2011

Role of the protein C receptor in cancer progression. Thrombosis Research 133(Suppl. 2): S85-S89, 2014

A role for p300/CREB binding protein genes in promoting cancer progression in colon cancer cell lines with microsatellite instability. Proceedings of the National Academy of Sciences of the United States of America 101(5): 1273-1278, 2004

Down-regulation of protein kinase, DNA-activated, catalytic polypeptide attenuates tumor progression and is an independent prognostic predictor of survival in prostate cancer. Urologic Oncology 35(3): 111.E15-111.E23, 2017

The role of metastasis-associated protein 1 in prostate cancer progression. Cancer Research 64(3): 825-829, 2004