+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

The role of the microbiota in inflammation, carcinogenesis, and cancer therapy

The role of the microbiota in inflammation, carcinogenesis, and cancer therapy

European Journal of Immunology 45(1): 17-31

Commensal microorganisms colonize barrier surfaces of all multicellular organisms, including those of humans. For more than 500 million years, commensal microorganisms and their hosts have coevolved and adapted to each other. As a result, the commensal microbiota affects many immune and nonimmune functions of their hosts, and de facto the two together comprise one metaorganism. The commensal microbiota communicates with the host via biologically active molecules. Recently, it has been reported that microbial imbalance may play a critical role in the development of multiple diseases, such as cancer, autoimmune conditions, and increased susceptibility to infection. In this review, we focus on the role of the commensal microbiota in the development, progression, and immune evasion of cancer, as well as some modulatory effects on the treatment of cancer. In particular, we discuss the mechanisms of microbiota-mediated regulation of innate and adaptive immune responses to tumors, and the consequences on cancer progression and whether tumors subsequently become resistant or susceptible to different anticancer therapeutic regiments.

(PDF emailed within 0-6 h: $19.90)

Accession: 056488057

Download citation: RISBibTeXText

PMID: 25328099

DOI: 10.1002/eji.201444972

Related references

Gut Microbiota as a Positive Potential Therapeutic Factor in Carcinogenesis: an Overview of Microbiota-Targeted Therapy. Journal of Gastrointestinal Cancer 2019, 2019

How two sites of inflammation promote carcinogenesis: The role of macrophages in inflammation associated carcinogenesis. Oncoimmunology 1(6): 951-953, 2012

Role of inflammation in pancreatic carcinogenesis and the implications for future therapy. Pancreatology 5(6): 514-529, 2005

Inflammation and cancer: role of phagocyte-generated oxidants in carcinogenesis. Blood 76(4): 655-663, 1990

The role of microbiota in cancer therapy. Current Opinion in Immunology 39: 75-81, 2016

From physiology to disease and targeted therapy: interleukin-6 in inflammation and inflammation-associated carcinogenesis. Archives of Toxicology 89(4): 541-554, 2015

Role of the Gut-Liver Axis in Liver Inflammation, Fibrosis, and Cancer: A Special Focus on the Gut Microbiota Relationship. Hepatology Communications 3(4): 456-470, 2019

Expression of NF-kB and COX2 in colorectal cancer among native Indonesians: the role of inflammation in colorectal carcinogenesis. Acta Medica Indonesiana 45(3): 187-192, 2014

Role of colonic microbiota in colorectal carcinogenesis: a systematic review. Revista Espanola de Enfermedades Digestivas 107(11): 659-671, 2017

Gastric microbiota and carcinogenesis: the role of non-Helicobacter pylori bacteria - A systematic review. Revista Espanola de Enfermedades Digestivas 108(9): 530-540, 2017

Mucins in pancreatic cancer: biological role, implications in carcinogenesis and applications in diagnosis and therapy. American Journal of Cancer Research 7(6): 1372-1383, 2017

Role of the microbiota in immunity and inflammation. Cell 157(1): 121-141, 2014

Suppression of inflammation by helminths: a role for the gut microbiota?. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences 370(1675), 2016

Role of the Gut Microbiota in Age-Related Chronic Inflammation. Endocrine Metabolic & Immune Disorders - Drug Targets 12(4): 361-367, 2012

Role of the gut microbiota in age-related chronic inflammation. Endocrine, Metabolic and Immune Disorders Drug Targets 12(4): 361-367, 2013