+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

The spatial regulation of meiotic recombination hotspots: are all DSB hotspots crossover hotspots?



The spatial regulation of meiotic recombination hotspots: are all DSB hotspots crossover hotspots?



Experimental Cell Research 318(12): 1347-1352



A key step for the success of meiosis is programmed homologous recombination, during which crossovers, or exchange of chromosome arms, take place. Crossovers increase genetic diversity but their main function is to ensure accurate chromosome segregation. Defects in crossover number and position produce aneuploidies that represent the main cause of miscarriages and chromosomal abnormalities such as Down's syndrome. Recombination is initiated by the formation of programmed double strand breaks (DSBs), which occur preferentially at places called DSB hotspots. Among all DSBs generated, only a small fraction is repaired by crossover, the other being repaired by other homologous recombination pathways. Crossover maps have been generated in a number of organisms, defining crossover hotspots. With the availability of genome-wide maps of DSBs as well as the ability to measure genetically the repair outcome at several hotspots, it is becoming more and more clear that not all DSB hotspots behave the same for crossover formation, suggesting that chromosomal features distinguish different types of hotspots.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 056500447

Download citation: RISBibTeXText

PMID: 22487095

DOI: 10.1016/j.yexcr.2012.03.025


Related references

Contrasted patterns of crossover and non-crossover at Arabidopsis thaliana meiotic recombination hotspots. Plos Genetics 9(11): E1003922, 2013

A novel method with improved power to detect recombination hotspots from polymorphism data reveals multiple hotspots in human genes. American Journal of Human Genetics 77(5): 781-794, 2005

N2O emission hotspots at different spatial scales and governing factors for small scale hotspots. Science of the Total Environment 407(7): 2325-2332, 2009

Trans-regulation of mouse meiotic recombination hotspots by Rcr1. Plos Biology 7(2): E36, 2009

Meiotic recombination hotspots. Annual Review of Genetics 29: 423-444, 1995

Hotspots for Initiation of Meiotic Recombination. Frontiers in Genetics 9: 521, 2018

Meiotic recombination hotspots in eukaryotes. Yi Chuan 27(4): 641-650, 2005

Meiotic recombination hotspots in plants. Biochemical Society Transactions 34(Pt 4): 531-534, 2006

The meiotic recombination hotspots of Schizosaccharomyces pombe. Genome Dynamics 5: 1-13, 2009

Persistence and loss of meiotic recombination hotspots. Genetics 169(4): 2319-2333, 2005

Meiotic recombination hotspots - a comparative view. Plant Journal 83(1): 52-61, 2015

Playing hide and seek with mammalian meiotic crossover hotspots. Trends in Genetics 23(6): 301-309, 2007

The Meiotic Recombination Activator PRDM9 Trimethylates Both H3K36 and H3K4 at Recombination Hotspots In Vivo. Plos Genetics 12(6): E1006146, 2016

Interplay between modifications of chromatin and meiotic recombination hotspots. Biology of the Cell 104(2): 51-69, 2012

Methods for Detecting Human Meiotic Recombination Hotspots. Critical Reviews in Eukaryotic Gene Expression 28(3): 205-215, 2018