Section 57
Chapter 56,510

The synthesis and antimicrobial activity of some 4-hydroxycoumarin derivatives

Zavrsnik, D.; Muratović, S.; Spirtović, S.; Softić, D.; Medić-Sarić, M.

Bosnian Journal of Basic Medical Sciences 8(3): 277-281


ISSN/ISBN: 1512-8601
PMID: 18816263
DOI: 10.17305/bjbms.2008.2933
Accession: 056509142

Download citation:  

Due to exceptional reactivity of 4-hydroxycoumarin, the synthesis of new coumarin derivatives of dimer and tetramer type has been carried out. The synthesis was carried out from 4-hydroxycoumarin and various aromatic aldehydes. In this way, compounds of the dimer 3,3'-(benzilidene)bis (4-hydroxycoumarin) type, as well as of the tetramer 3,3',3'',3'''-(1,4-dimethylenphenyl)tetra (4-hydroxycoumarin) type were prepared. The newly synthesized derivatives contain different functional groups, and as such they could exhibit microbiological activity. Therefore, we tested the microbiological activity of these derivatives on various species of bacteria and fungi. The tested compounds have shown different activity in terms of growth inhibition of microorganisms. Newly synthesized derivatives exhibit antibacterial activities, manifested as growth inhibition on Gram-positive bacteria types (Bacillus, Staphylococcus), while the activity against Candida was much weaker. The same compound did not show any antimicrobial activity against two Gram-negative bacteria types (Escherichia coli, Pseudomonas aeruginosa). The compound 1 showed the best microbiological activity. The obtained results confirmed its good antibacterial and antimycotic activities against different microorganisms.

PDF emailed within 0-6 h: $19.90