Section 57
Chapter 56,533

The value of diffusion-weighted imaging for monitoring the chemotherapeutic response of osteosarcoma: a comparison between average apparent diffusion coefficient and minimum apparent diffusion coefficient

Oka, K.; Yakushiji, T.; Sato, H.; Hirai, T.; Yamashita, Y.; Mizuta, H.

Skeletal Radiology 39(2): 141-146


ISSN/ISBN: 1432-2161
PMID: 19924412
DOI: 10.1007/s00256-009-0830-7
Accession: 056532600

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The objective of this study was to evaluate whether the average apparent diffusion coefficient (ADC) or the minimum ADC is more useful for evaluating the chemotherapeutic response of osteosarcoma. Twenty-two patients with osteosarcoma were examined in this study. Diffusion-weighted (DW) and magnetic resonance (MR) images were performed for all patients before and after chemotherapy. The pre- and post-chemotherapy values were obtained both in the average and minimum ADC. The pre-chemotherapy values of the average ADC and minimum ADC respectively were compared with the post-chemotherapy values. In addition, the ADC ratios ([ADC(post) - ADC(pre)] / ADC(pre)) were calculated using the average ADC and the minimum ADC. Twenty-two patients with osteosarcomas were divided into two groups, those with a good response to chemotherapy (> or = 90% tumor necrosis, n = 7) and those with a poor response (< 90% tumor necrosis, n = 15). The average ADC ratio and the minimum ADC ratio of the two groups were compared. With both the average ADC and the minimum ADC, post-chemotherapy values were significantly higher than pre-chemotherapy values (P < 0.05). The patients with a good response had a significantly higher minimum ADC ratio than those with a poor response (1.01 + or - 0.22 and 0.55 + or - 0.29 respectively, P < 0.05). However, with regard to the average ADC ratio, no significant difference was observed between the two groups (0.66 + or - 0.18 and 0.46 + or - 0.31 respectively, P = 0.19). The minimum ADC is useful for evaluating the chemotherapeutic response of osteosarcoma.

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