+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Therapeutic and prophylactic effect of intermittent preventive anti-malarial treatment in infants (IPTi) from Ghana and Gabon



Therapeutic and prophylactic effect of intermittent preventive anti-malarial treatment in infants (IPTi) from Ghana and Gabon



Malaria Journal 7: 198



Intermittent preventive treatment in infants (IPTi) with sulphadoxine-pyrimethamine (SP) reduces the incidence of malaria episodes in young children. The exact mechanism by which the protective effect is mediated needs to be defined. This study aimed to investigate therapeutic, prophylactic, and possible exceeding effects of SP-based IPTi in two clinical trials. Protective efficacies from two IPTi trials performed in Kumasi, Ghana, and Lambaréné, Gabon, were assessed for overlapping time series of 61 days. For six-months periods after each of three IPTi doses a multivariate Poisson regression model with the respective cohort as co-variate was generated and effect modification of protective efficacy with time strata was evaluated by log-likelihood tests. Protective efficacies were not significantly different between the two study cohorts. Study-cohort corrected protective efficacy was highest for the first 61 days after each IPTi application and decreased continuously. For the first 61 days after IPTi-1, IPTi-2, and IPTi-3 the protective efficacy was 71%, 44%, and 43%, respectively. A reduction of the malaria incidence rate was detectable for the first 60, 30 and 40 days after IPTi-1, IPTi-2 and IPTi-3 drug application, respectively. After IPTi-3 a higher risk for malaria could be seen after day 60. This effect was mainly based on the overwhelming influence of the Kumasi cohort. The results suggest that SP-based IPTi mainly works through a therapeutic and prophylactic effect over 30 to 60 days after drug application and that a sustained effect beyond post-treatment prophylaxis might be very low. Data analysis from clinical trials NCT ID # 00206739 (Kumasi Trial) and NCT ID # 00167843 (Lambaréné Trial), http://www.clinicaltrials.gov.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 056545551

Download citation: RISBibTeXText

PMID: 18828899

DOI: 10.1186/1475-2875-7-198


Related references

Therapeutic and prophylactic effect of intermittent preventive anti-malarial treatment in infants from Ghana and Gabon. Malaria Journal: (1 Ober), 2008

Cost-effectiveness of intermittent preventive treatment of malaria in infants (IPTi) for averting anaemia in Gabon: a comparison between intention to treat and according to protocol analyses. Malaria Journal 10: 305, 2011

Malaria incidence and efficacy of intermittent preventive treatment in infants (IPTi). Malaria Journal 6: 163-163, 2007

The promise and potential challenges of intermittent preventive treatment for malaria in infants (IPTi). Malaria Journal 4: 33, 2005

Community effectiveness of intermittent preventive treatment for infants (IPTi) in rural southern Tanzania. American Journal of Tropical Medicine and Hygiene 82(5): 772-781, 2010

Community response to intermittent preventive treatment of malaria in infants (IPTi) in Papua New Guinea. Malaria Journal 9: 369, 2010

Community response to intermittent preventive treatment delivered to infants (IPTi) through the EPI system in Manhica, Mozambique. Tropical Medicine and International Health 11(11): 1670-1678, 2006

Selection of antimalarial drug resistance after intermittent preventive treatment of infants and children (IPTi/c) in Senegal. American Journal of Tropical Medicine and Hygiene 88(6): 1124-1129, 2013

Cost-effectiveness of malaria intermittent preventive treatment in infants (IPTi) in Mozambique and the United Republic of Tanzania. Bulletin of the World Health Organization 87(2): 123-129, 2009

Protective efficacy of intermittent preventive treatment of malaria in infants (IPTi) using sulfadoxine-pyrimethamine and parasite resistance. Plos one 5(9): E12618, 2010

The acceptability of intermittent preventive treatment of malaria in infants (IPTi) delivered through the expanded programme of immunization in southern Tanzania. Malaria Journal 7: 213, 2008

Cluster-randomized study of intermittent preventive treatment for malaria in infants (IPTi) in southern Tanzania: evaluation of impact on survival. Malaria Journal 10: 387, 2011

Community response to intermittent preventive treatment of malaria in infants (IPTi) delivered through the expanded programme of immunization in five African settings. Malaria Journal 8: 191, 2009

Intermittent preventive treatment against malaria in infants in Gabon. 2007