+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Toxoplasma gondii antibody profile in HIV-1-infected and uninfected pregnant women and the impact on congenital toxoplasmosis diagnosis in Rio de Janeiro, Brazil



Toxoplasma gondii antibody profile in HIV-1-infected and uninfected pregnant women and the impact on congenital toxoplasmosis diagnosis in Rio de Janeiro, Brazil



Brazilian Journal of Infectious Diseases 16(2): 170-1174



Compare the anti-T. gondii IgG titer between HIV-1 infected and non HIV-1 infected pregnant women and report three cases of congenital toxoplasmosis resulting from reactivation of infection during pregnancy of HIV-1 infected women. This study was conducted among 2,270 pregnant women with chronic Toxoplasma gondii infection (absence of IgM and presence of IgG), including 82 HIV-1 infected and 2,188 non-infected women. The average anti-T. gondii IgG titer was 127 for the 2,188 non-HIV-1 infected women, and 227 for the 82 HIV-1-infected women (p = 0,007). These results suggested that higher anti-T. gondii IgG titers in HIV-1-infected pregnant women may not be indicative of an elevated risk for fetal infection. In this study three cases of congenital toxoplasmosis that resulted from infection reactivation during pregnancy of HIV-1-infected women were manifested by fetal death, symptomatic infection, and infant without symptoms, respectively. In two of these women, a ten-fold increase in IgG levels above used cutoff was observed (2,320 UI/mL and 3,613 UI/mL, respectively). In the third pregnant women anti-T. gondii IgG titers during pregnancy did not rise despite the occurrence of congenital toxoplasmosis (204; 198; 172 UI/mL). Congenital toxoplasmosis resulting reactivation of infection during pregnancy in the studied group leads us to believe that it is a public health problem, especially in our population, in which seroprevalence of T. gondii infections is high. These findings also suggest that special attention is necessary during pregnancy, because the serologic diagnosis may not be indicative of toxoplasmosis reactivation.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 056623435

Download citation: RISBibTeXText

PMID: 22552460


Related references

Toxoplasma gondii antibody profile in HIV-1-infected and uninfected pregnant women and the impact on congenital toxoplasmosis diagnosis in Rio de Janeiro, Brazil. Brazilian Journal of Infectious Diseases 16(2): 170-174, 2012

Toxoplasma gondii antibody profile in HIV-infected pregnant women and the risk of congenital toxoplasmosis. European Journal of Clinical Microbiology and Infectious Diseases 28(4): 345-351, 2008

Classification system and case definitions of Toxoplasma gondii infection in immunocompetent pregnant women and their congenitally infected offspring. European Research Network on Congenital Toxoplasmosis. European Journal of Clinical Microbiology and Infectious Diseases 15(10): 799-805, 1996

Co-infection of Toxoplasma gondii with HBV in HIV-infected and uninfected pregnant women in Burkina Faso. Pakistan Journal of Biological Sciences 12(17): 1188-1193, 2010

Cytokine production assayed by RT-PCR in pregnant mice infected by Toxoplasma gondii as a model of congenital toxoplasmosis. Japanese Journal of Tropical Medicine and Hygiene 25(2): 59-67, 1997

Association of the presence of residual anti-Toxoplasma gondii IgM in pregnant women and their respective family groups in Miracema, Northwest Rio de Janeiro, Brazil. Memorias do Instituto Oswaldo Cruz 103(6): 591-594, 2008

High predictive value of Toxoplasma gondii IgG antibody levels in HIV-infected patients for diagnosis of cerebral toxoplasmosis. European Journal of Clinical Microbiology and Infectious Diseases 15(11): 869-872, 1996

Toxoplasma gondii genotypes isolated from pregnant women with follow-up of infected children in southern Brazil. Transactions of the Royal Society of Tropical Medicine and Hygiene 108(4): 244-246, 2014

Prevalence of toxoplasmosis in pregnant women and vertical transmission of Toxoplasma gondii in patients from basic units of health from Gurupi, Tocantins, Brazil, from 2012 to 2014. Plos One 10(11): E0141700, 2016

Prevalence and risk factors for Toxoplasma gondii infection among pregnant and postpartum women attended at public healthcare facilities in the City of Niterói, State of Rio de Janeiro, Brazil. Revista Da Sociedade Brasileira de Medicina Tropical 46(2): 200-207, 2013

Immunochemical identification and detection of a 36-kDa Toxoplasma gondii circulating antigen in sera of infected women for laboratory diagnosis of toxoplasmosis. Journal of Immunoassay and Immunochemistry 27(1): 45-60, 2006

Role of Toxoplasma gondii HSP70 and Toxoplasma gondii HSP30/bag1 in antibody formation and prophylactic immunity in mice experimentally infected with Toxoplasma gondii. Microbiology and Immunology 43(5): 471-479, 1999

Profile of pregnant women and children treated at a reference center for congenital toxoplasmosis in the northern state of Minas Gerais, Brazil. Revista Da Sociedade Brasileira de Medicina Tropical 45(1): 55-59, 2012

Toxoplasmosis in the Caribbean islands: literature review, seroprevalence in pregnant women in ten countries, isolation of viable Toxoplasma gondii from dogs from St. Kitts, West Indies with report of new T. gondii genetic types. Parasitology Research 115(4): 1627-1634, 2016

IgM antibodies to Toxoplasma gondii in the diagnosis of congenital toxoplasmosis. Giornale di Malattie Infettive e Parassitarie 38(6): 730-732, 1986