+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Trachoma and ocular Chlamydia trachomatis rates in children in trachoma-endemic communities enrolled for at least three years in the Tanzania National Trachoma Control Programme



Trachoma and ocular Chlamydia trachomatis rates in children in trachoma-endemic communities enrolled for at least three years in the Tanzania National Trachoma Control Programme



Tanzania Journal of Health Research 11(3): 103-110



Trachoma, a blinding eye disease caused by repeated and prolonged infection with Chlamydia trachomatis, is a significant public health problem for sub-Saharan Africa. Tanzania has had a National Trachoma Task Force since 1999, working on trachoma control in endemic districts. The objective of this study was twofold: first, to determine the current status of infection and clinical trachoma in these districts in Tanzania, and second, to determine if a combination of clinical signs could be used as a surrogate for infection. We conducted a survey for trachoma and infection with C. trachomatis in 75 villages in eight districts of Kongwa, Kilosa, Mpwapwa, Bahi, Kondoa, Manyoni, Monduli and Iramba in Tanzania, which have previously been shown to be endemic. In each village, a random sample of households, and of children within households, was taken for examination. Trachoma was graded using the World Health Organization system, which we expanded, and a swab taken to determine presence of infection. The rates of trachoma ranged from 0% in Iramba District to 15.17% in Monduli District, with large variation in villages within districts. Infection rates were generally lower than trachoma rates, as expected, and most districts had villages with no infection. A combination of clinical signs of trachoma in children, when absent, showed very high specificity for identifying villages with no infection. We conclude that these signs might be useful for monitoring absence of infection in villages, and that districts with trachoma prevalence between 10% and 15% should have village level rapid surveys to avoid unnecessary mass treatment.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 056625656

Download citation: RISBibTeXText

PMID: 20734706


Related references

Infection with Chlamydia trachomatis Immunotype J Associated with Trachoma in Children in an Area Previously Endemic for Trachoma. Journal of Infectious Diseases 151(6): 1034-1036, 1985

Infectious with chlamydia trachomatis immunotype j associated with trachoma in children in an area previously endemic for trachoma. Journal of Infectious Diseases 151(6): 1034-1036, 1985

Trachoma and ocular Chlamydia trachomatis were not eliminated three years after two rounds of mass treatment in a trachoma hyperendemic village. Investigative Ophthalmology & Visual Science 48(4): 1492-1497, 2007

Risk factors for active trachoma and ocular Chlamydia trachomatis infection in treatment-naïve trachoma-hyperendemic communities of the Bijagós Archipelago, Guinea Bissau. Plos Neglected Tropical Diseases 8(6): E2900, 2014

Detection of Chlamydia trachomatis ocular infection in trachoma-endemic communities by rRNA amplification. Investigative Ophthalmology and Visual Science 50(1): 90-94, 2009

Extra ocular infections in children in areas with endemic trachoma chlamydia trachomatis. Journal of Infectious Diseases 143(6): 853, 1981

The easiest children to reach are most likely to be infected with ocular Chlamydia trachomatis in trachoma endemic areas of Niger. Plos Neglected Tropical Diseases 7(1): E1983, 2013

Population-based analysis of ocular Chlamydia trachomatis in trachoma-endemic West African communities identifies genomic markers of disease severity. Genome Medicine 10(1): 15, 2018

Prevalence and distribution of active trachoma in children of less than five years of age in trachoma endemic regions of Oman in 2005. Ophthalmic Epidemiology 13(3): 167-172, 2006

Trachoma agent chlamydia trachomatis in the psittacosis lymphogranuloma venereum trachoma group simple means of identification. Comptes Rendus Des Seances De La Societe De Biologie Et De Ses Filiales: 1099-1102, 1969

Does the diagnosis of trachoma adequately identify ocular chlamydial infection in trachoma-endemic areas?. Journal of Infectious Diseases 187(10): 1669-1673, 2003

Field evaluation of the Cepheid GeneXpert Chlamydia trachomatis assay for detection of infection in a trachoma endemic community in Tanzania. Plos Neglected Tropical Diseases 7(7): E2265, 2013

Number of years of annual mass treatment with azithromycin needed to control trachoma in hyper-endemic communities in Tanzania. Journal of Infectious Diseases 204(2): 268-273, 2011

Profound and sustained reduction in Chlamydia trachomatis in The Gambia: a five-year longitudinal study of trachoma endemic communities. Plos Neglected Tropical Diseases 4(10):, 2010

The impact of a single round of community mass treatment with azithromycin on disease severity and ocular Chlamydia trachomatis load in treatment-naïve trachoma-endemic island communities in West Africa. Parasites and Vectors 10(1): 624, 2017