+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn

+ Translate
+ Recently Requested

Tramadol reduces myocardial infarct size and expression and activation of nuclear factor kappa B in acute myocardial infarction in rats

Tramadol reduces myocardial infarct size and expression and activation of nuclear factor kappa B in acute myocardial infarction in rats

European Journal of Anaesthesiology 26(12): 1048-1055

Some anaesthetics show cardioprotective properties, but the underlying mechanism remains elusive. The aim of this study was to investigate the cardioprotective effect of tramadol and the association of the effect with the changes in expression and activation of nuclear factor kappa B (NF-kappaB) in acute myocardial infarction in a rodent model. Male Sprague-Dawley rats were randomly divided into three groups: the sham group, exposure of anterior parts of the heart was carried out without ligation of the coronary artery; coronary artery occlusion (CAO) group, ligation of the left anterior descending branch of the coronary artery was performed; and the group in which the animals were pretreated with tramadol (12.5 mg kg(-1), intravenously) before the CAO (T + CAO). The infarct size, expression of NF-kappaB subunit p65 mRNA and protein and intercellular adhesion molecule-1 mRNA were examined. Isolated nucleus suspension was analysed by flow cytometry to determine activation of NF-kappaB. The area at risk (percentage of left ventricle) was 46.4 +/- 6.2 and 48.2 +/- 5.9% in the CAO and T + CAO groups, respectively, showing no statistical difference in area at risk/left ventricle between the two groups (P > 0.05). The infarct size (percentage of risk area) was reduced from 44.9 +/- 6.8% in CAO animals to 31.6 +/- 7.7% in T + CAO animals. The reduction of infarct size in the T + CAO group was statistically significant (P < 0.05). Expression of NF-kappaB and its mRNA and intercellular adhesion molecule-1 mRNA was significantly increased in the CAO group compared with the sham group and was significantly decreased in the T + CAO animals. Flow cytometry assay revealed that tramadol attenuated the activation of NF-kappaB by 13.4%. Tramadol may protect myocardium against acute myocardial ischaemic injury and could reduce myocardial infarct size, which may be associated with the expression and activation of NF-kappaB.

(PDF emailed within 0-6 h: $19.90)

Accession: 056631122

Download citation: RISBibTeXText

PMID: 19829116

DOI: 10.1097/EJA.0b013e32832c785d

Related references

A multicenter, randomized, controlled study of mechanical left ventricular unloading with counterpulsation to reduce infarct size prepercutaneous coronary intervention for acute myocardial infarction: rationale and design of the Counterpulsation Reduces Infarct Size Acute Myocardial Infarction trial. American Heart Journal 162(1): 47-55.E1, 2011

Inhibition of the activation of nuclear factor kappa B to reduce myocardial reperfusion injury and infarct size. Cardiovascular Research 63(1): 8-10, 2004

Early Use of N-acetylcysteine With Nitrate Therapy in Patients Undergoing Primary Percutaneous Coronary Intervention for ST-Segment-Elevation Myocardial Infarction Reduces Myocardial Infarct Size (the NACIAM Trial [N-acetylcysteine in Acute Myocardial Infarction]). Circulation 136(10): 894-903, 2017

Mechano-chronotropic Unloading During the Acute Phase of Myocardial Infarction Markedly Reduces Infarct Size via the Suppression of Myocardial Oxygen Consumption. Journal of Cardiovascular Translational Research: -, 2018

Transfusion of fresh but not old stored blood reduces infarct size and improves cardiac function after acute myocardial infarction in anemic rats*. Critical Care Medicine 40(3): 740-746, 2012

Dimethyl fumarate, a small molecule drug for psoriasis, inhibits Nuclear Factor-kappaB and reduces myocardial infarct size in rats. European Journal of Pharmacology 586(1-3): 251-258, 2008

Beneficial effects of pre-infarction angina on the myocardial infarct size, myocardial viability, and functional recovery in reperfused acute myocardial infarction. European Heart Journal 23(Abstract Supplement): 383, August-September, 2002

Short-term pretreatment with atorvastatin attenuates left ventricular dysfunction, reduces infarct size and apoptosis in acute myocardial infarction rats. International Journal of Clinical and Experimental Medicine 7(12): 4799-4808, 2015

Anti-inflammatory effect of Guan-Xin-Er-Hao via the nuclear factor-kappa B signaling pathway in rats with acute myocardial infarction. Experimental Animals 59(2): 207-214, 2010

Effects of rosiglitazone on myocardial fibrosis and expression of nuclear factor-kappa B activation and connective tissue growth factor in diabetic rats. Zhongguo Xinyao yu Linchuang Zazhi 27(3): 169-172, 2008

Myocardial infarction in diabetic rats: role of hyperglycaemia on infarct size and early expression of hypoxia-inducible factor 1. Diabetologia 45(8): 1172-1181, 2002

Established beta-blockade reduces infarct size in acute myocardial infarction. Journal of the American College of Cardiology 21(2 SUPPL A): 150A, 1993

Defibrinogenation reduces infarct size in a canine model of acute myocardial infarction. Journal of the American College of Cardiology 13(2 SUPPL A): 125A, 1989

Role of cellular proteinases in acute myocardial infarction. II. Influence of in vivo suppression of myocardial proteolysis by antipain, leupeptin and pepstatin on myocardial infarct size in the rat. Journal of the American College of Cardiology 2(4): 681-688, 1983

Carvedilol (Kredex®) Reduces Infarct Size in a Canine Model of Acute Myocardial Infarction. Pharmacology 43(3): 113-120, 1991