+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Treatment for BK virus: incidence, risk factors and outcomes for kidney transplant recipients in the United States



Treatment for BK virus: incidence, risk factors and outcomes for kidney transplant recipients in the United States



Transplant International 22(6): 626-634



There has been a notable rise of BK virus among kidney transplant recipients. Single-center reports have identified risk factors for development of BK virus. However, there has not been an assessment of risk factors and incidence of this complication at a national level. This study utilized newly collected follow-up information from the national SRTR database to investigate incidence, risk factors and outcomes for solitary kidney transplant recipients associated with treatment for BK virus (TBKV) from 2004 to 2006. Logistic and Cox models were utilized to assess risk factors and evaluate graft survival associated with TBKV. Incidence of TBKV was 1.6% at 6 months and 2.6% at 1 year following transplantation. Patients with and without TBKV at 6 months had 79% and 90% 3-year overall graft survival respectively. Risk factors included advanced donor age, pediatric, African American and male recipients, human leukocyte antigen-mismatching and tacrolimus and thymoglobulin induction as baseline immunosuppression. Acute rejection episodes were more frequent prior to and following TBKV. TBKV is a common and rising incidence, varies based on transplant characteristics and should be included as a safety endpoint in studies investigating immunosuppressive protocols. Careful monitoring and further understanding of disease etiology and treatment strategies are needed.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 056667290

Download citation: RISBibTeXText

PMID: 19207187

DOI: 10.1111/j.1432-2277.2009.00842.x


Related references

Incidence of and Risk Factors for Skin Cancer in Organ Transplant Recipients in the United States. JAMA Dermatology 153(3): 296-303, 2017

Incidence, Risk Factors, and Outcomes of Clostridium difficile Infections in Kidney Transplant Recipients. Transplantation 102(9): 1576-1581, 2018

Incidence, Risk Factors, Clinical Management, and Outcomes of Posttransplant Lymphoproliferative Disorder in Kidney Transplant Recipients. Progress in Transplantation 29(2): 185-193, 2019

Medication errors and adverse drug events in kidney transplant recipients: incidence, risk factors, and clinical outcomes. PharmacoTherapy 32(12): 1053-1060, 2012

Long-term outcomes and transmission rates in hepatitis C virus-positive donor to hepatitis C virus-negative kidney transplant recipients: Analysis of United States national data. Clinical Transplantation 31(10):, 2017

Treatment for presumed BK polyomavirus nephropathy and risk of urinary tract cancers among kidney transplant recipients in the United States. American Journal of Transplantation 18(1): 245-252, 2018

Risk factors for early-onset and late-onset post-transplant lymphoproliferative disorder in kidney recipients in the United States. American Journal of Hematology 86(2): 206-209, 2011

Pneumocystis jiroveci pneumonia in kidney and simultaneous pancreas kidney transplant recipients in the present era of routine post-transplant prophylaxis: risk factors and outcomes. Bmc Nephrology 19(1): 332, 2018

Impact of pre-existing hepatitis B infection on the outcomes of kidney transplant recipients in the United States. Clinical Journal of the American Society of Nephrology 6(6): 1481-1487, 2011

Colorectal surgery in kidney transplant recipients: a decade of trends and outcomes in the United States. American Surgeon 79(10): 1026-1033, 2013

The association of community health indicators with outcomes for kidney transplant recipients in the United States. Archives of Surgery 147(6): 520-526, 2012

Prevalence and Risk Factors of BK Viremia and Clinical Impact of BK Virus Surveillance on Outcomes in Kidney Transplant Recipients: A Single-Center Cross-Sectional Study. Experimental and Clinical Transplantation 2019:, 2019

Risk of Renal Cell Carcinoma Among Kidney Transplant Recipients in the United States. American Journal of Transplantation 16(12): 3479-3489, 2016

Incidence and outcomes of BK virus allograft nephropathy among ABO- and HLA-incompatible kidney transplant recipients. Clinical Journal of the American Society of Nephrology 7(8): 1320-1327, 2012

Beyond the NIH Multicenter HIV Transplant Trial Experience: Outcomes of HIV+ Liver Transplant Recipients Compared to HCV+ or HIV+/HCV+ Coinfected Recipients in the United States. Clinical Infectious Diseases 61(7): 1054-1062, 2015