+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Treatment of frozen shoulder with intra-articular injection of botulinum toxin in shoulder joints



Treatment of frozen shoulder with intra-articular injection of botulinum toxin in shoulder joints



Medical Hypotheses 77(2): 305-307



Frozen shoulder, or adhesive capsulitis, is a disease of chronic inflammation and fibrosis involving the shoulder joints. The disease is challenging in clinical practice due to painful treatment course, with disease evolution usually lasting weeks or even months, causing significant discomfort and functional loss. Botulinum toxin (BTX) has been discovered to possess abilities in pain management at various clinical diseases. The actual mechanism is still under investigation, and involves inhibition of neurotransmitter release. In addition, BTX is also found to retard process of fibrosis, which is also a key issue in pathogenesis of frozen shoulder. Therefore, we hypothesize that intra-articular injection of BTX can be an effective alternative for treatment of frozen shoulder.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 056673562

Download citation: RISBibTeXText

PMID: 21640488

DOI: 10.1016/j.mehy.2011.05.001


Related references

Efficacy of intra-articular injection of botulinum toxin type A in refractory hemiplegic shoulder pain. Archives of Physical Medicine and Rehabilitation 92(7): 1034-1037, 2011

Intra-articular injection of botulinum toxin type A for shoulder pain in glenohumeral osteoarthritis: a case series summary and review of the literature. Journal of Pain Research 11: 1239-1245, 2018

Intra-articular botulinum toxin type A (IA-BoNT/A) significantly decreases shoulder pain in patients with refractory shoulder pain due to osteoarthritis: A randomized double-blind placebo controlled trial. 2007

Intra-articular botulinum toxin type A (IA-BoNT/A) significantly decreases shoulder pain in patients with refractory shoulder arthritis pain: A randomized double-blind placebo-controlled trial. 2008

Representative survey of frozen shoulder questionnaire responses from the Japan Shoulder Society: What are the appropriate diagnostic terms for primary idiopathic frozen shoulder, stiff shoulder or frozen shoulder?. Journal of Orthopaedic Science 2019, 2019

Intra-articular injection, subacromial injection, and hydrodilatation for primary frozen shoulder: a randomized clinical trial. Journal of Shoulder and Elbow Surgery 25(3): 376-383, 2016

Intramuscular Botulinum Toxin-A Reduces Hemiplegic Shoulder Pain: A Comparision Study With Intra-Articular Triamcinolone Acetonide. American Journal of Physical Medicine & Rehabilitation 85(3): 252-253, 2006

Intra-articular botulinum toxin A for refractory shoulder pain: a randomized, double-blinded, placebo-controlled trial. Translational Research 153(5): 205-216, 2009

The timing of elective shoulder surgery after intra-articular shoulder injection affects postoperative infection risk. Journal of Shoulder and Elbow Surgery 25(6): E178-E179, 2016

Arthroscopic capsular release for idiopathic frozen shoulder with intra-articular injection and a controlled manipulation. Annals of the Royal College of Surgeons of England 96(1): 55-60, 2014

Effects of intra-articular steroid injection before pan-capsular release in patients with refractory frozen shoulder. Knee Surgery Sports Traumatology Arthroscopy 23(5): 1536-1541, 2015

Comparison between NSAID and intra-articular corticosteroid injection in frozen shoulder of diabetic patients; a randomized clinical trial. Experimental and Clinical Endocrinology and Diabetes 121(2): 75-79, 2013

Comparative Efficacy of Intra-Articular Steroid Injection and Distension in Patients With Frozen Shoulder: A Systematic Review and Network Meta-Analysis. Archives of Physical Medicine and Rehabilitation 99(2): 409, 2018

Comparative Efficacy of Intra-Articular Steroid Injection and Distension in Patients With Frozen Shoulder: A Systematic Review and Network Meta-Analysis. Archives of Physical Medicine and Rehabilitation 99(7): 1383-1394.E6, 2018

Frozen shoulder syndrome: comparison of oral route corticosteroid and intra-articular corticosteroid injection. Medical Journal of Malaysia 59(3): 312-316, 2004