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Treatment of recurrent vulvo-vaginal candidiasis with sustained-released butoconazole pessary



Treatment of recurrent vulvo-vaginal candidiasis with sustained-released butoconazole pessary



Singapore Medical Journal 53(12): E269-E271



Vulvo-vaginal candidiasis (VVC) is a common infection among women. 5% of women with acute infection experience recurrent vulvo-vaginal candidiasis (RVVC). There is currently no optimal or recommended regime for RVVC. Although antifungal agents, such as imidazoles, have been successfully used as a first-line treatment for acute VVC, its effectiveness is limited in RVVC. This could be due to patient factors, drug application (such as leakage) or dosing factors. A sustained-release (SR) bioadhesive vaginal cream (2% butoconazole nitrate) has incorporated VagiSite technology, a topical drug delivery system that allows SR of the drug. We describe its efficacy and the successful use of a butoconazole-SR formulation in the treatment of two cases of RVVC.

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Accession: 056678405

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PMID: 23268172


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