Triple combinations of lower and longer alkyl gallates and oxacillin improve antibiotic synergy against methicillin-resistant Staphylococcus aureus
Shibata, H.; Nakano, T.; Parvez, M.A.K.; Furukawa, Y.; Tomoishi, A.; Niimi, S.; Arakaki, N.; Higuti, T.
Antimicrobial Agents and ChemoTherapy 53(5): 2218-2220
2009
ISSN/ISBN: 1098-6596
PMID: 19223633
DOI: 10.1128/aac.00829-08
Accession: 056693734
Using liposome systems, we found that gallates with short alkyl chains were located in the external medium and those with longer alkyl chains were located in the surface region of lipid bilayer. Combinations of these gallates remarkably reduced oxacillin MICs against methicillin-resistant Staphylococcus aureus to below the antibiotic breakpoint (< or = 2 microg/ml).