+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Ultrastructural changes of olfactory epithelium of the patients with olfactory disorder caused by common cold



Ultrastructural changes of olfactory epithelium of the patients with olfactory disorder caused by common cold



Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 42(11): 826-829



The study focus on the olfactory changes post upper respiratory infection, through observation of nasal mucosa and it's ultrastructural changes. Olfactory test was performed by odor threshold and identification test (T&T olfactometry). The specimens of olfactory epithelium (OE) were obtained from 10 patients with anosmia or olfactory disorder post upper respiratory infection. All specimens were obtained under endoscope. Transmission electron microscope (TEM) was used to observe the ultrastructural changes of each group. Under the TEM, the surface ultrastructure of the OE from patients showed following abnormal changes: (1) Normal epithelium structural characteristics maintained but clearance between cells appeared wider. (2) Olfactory vesicles reduced obviously, even if the olfactory vesicles existed, the olfactory cilia showed reduction. Some olfactory vesicles still existed, but the number of olfactory cilia reduced. Some olfactory vesicles changed their shape due to vacuolization. (3) Surface microvillus of the supporting cells disappeared. (4) The nuclei of supporting cell changed the shape or karyopyknosis, olfactory dendrites were shorter and wider than normal, and organelles reduced. There is close relationship between ultrastructural changes and olfactory disorders post upper respiratory infection. Reduced olfactory vesicles, cilia and disappeared microvillus of the supporting cells are the main reasons for the patient's olfactory disorder.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 056743555

Download citation: RISBibTeXText

PMID: 18300444


Related references

Ultrastructural study of olfactory epithelium of a patient with olfactory disturbance caused by the common cold. Practica Otologica Kyoto 83(12): 1807-1811, 1990

Relationships among olfactory epithelium appearance olfactory test results and prognosis analysis of eight patients with olfactory disturbances caused by the common cold. Practica Otologica Kyoto 83(3): 383-390, 1990

Examination of human olfactory epithelium in patients with olfactory disturbance caused by common cold immunohistochemical findings. Practica Otologica Kyoto 81(5): 753-757, 1988

Morphological, histological and ultrastructural study of the olfactory mucosa. I. The olfactory epithelium. Anales Otorrinolaringologicos Ibero-Americanos 12(4): 291-304, 1985

An ultrastructural and immunohistological study of the rat olfactory epithelium: unique properties of olfactory sensory cells. Differentiation 29(3): 243-253, 1985

Ultrastructural localization of antibodies to olfactory epithelial specific glycoproteins gp95 olfactomedin and 9 oe and 5 oe antigens in the frogs olfactory epithelium. Chemical Senses 16(5): 554-555, 1991

Histogenesis of olfactory neuroepithelioma an ultrastructural immunohistological and biochemical investigation of chemically induced tumors of the olfactory epithelium of rats. Neuropathology & Applied Neurobiology 11(4): 327-328, 1985

Some ultrastructural peculiarities of secondary cells and of the olfactory epithelium secretion in some fish species related to a possible mechanism of olfactory perception. Tsitologiya Leningrad 169: 1089-1094, 1974

Ultrastructural characteristics of secretory cells and of the olfactory epithelium secretion in some fish species in relation to a possible olfactory perception mechanism. Tsitologiya 16(9): 1089-1094, 1974

The mechanisms underlying olfactory deficits in apolipoprotein E-deficient mice: focus on olfactory epithelium and olfactory bulb. Neurobiology of Aging 62: 20-33, 2018

Effects of transplanting olfactory ensheathing cells on recovery of olfactory epithelium after olfactory nerve transection in rats. Medical Science Monitor 14(10): Br198-Br204, 2008

Aging in the rat olfactory system: relative stability of piriform cortex contrasts with changes in olfactory bulb and olfactory epithelium. Journal of Comparative Neurology 235(4): 519-528, 1985

Valproic acid ameliorates olfactory dysfunction in APP/PS1 transgenic mice of Alzheimer's disease: Ameliorations from the olfactory epithelium to the olfactory bulb. Pharmacology Biochemistry and Behavior 144: 53-59, 2016

Aging in the mouse olfactory system Correlation of changes in the olfactory epithelium and olfactory behaviour. Zoological Science 16(Suppl ): 93, 1999

Ultrastructural localization of connexins (Cx36, Cx43, Cx45), glutamate receptors and aquaporin-4 in rodent olfactory mucosa, olfactory nerve and olfactory bulb. Journal of Neurocytology 34(3-5): 307-341, 2005