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Unusual regulation of a STAT protein by an SLC6 family transporter in C. elegans epidermal innate immunity



Unusual regulation of a STAT protein by an SLC6 family transporter in C. elegans epidermal innate immunity



Cell Host & Microbe 9(5): 425-435



The cuticle and epidermis of Caenorhabditis elegans provide the first line of defense against invading pathogens. Upon invasion by the fungal pathogen Drechmeria coniospora, C. elegans responds by upregulating the expression of antimicrobial peptides (AMPs) in the epidermis via activation of at least two pathways, a neuroendocrine TGF-? pathway and a p38 MAPK pathway. Here, we identify the sodium-neurotransmitter symporter SNF-12, a member of the solute carrier family (SLC6), as being essential for both these immune signaling pathways. We also identify the STAT transcription factor-like protein STA-2 as a direct physical interactor of SNF-12 and show that the two proteins function. Graphical : Highlights: C. elegans SNF-12 regulates antimicrobial peptide expression upon fungal infection SNF-12 physically interacts with a STAT-like transcription factor, STA-2 SNF-12 and STA-2 function cell autonomously and associate with endocytic vesicles snf-12 and sta-2 act downstream of the TGF-? and p38 MAPK host defense pathways.

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Accession: 056772335

Download citation: RISBibTeXText

PMID: 21575913

DOI: 10.1016/j.chom.2011.04.011


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