EurekaMag
+ Translate
+ Most Popular
Gaucher's disease;thirty-two years experience at Siriraj Hospital
A study of Macrobathra Meyrick from China (Lepidoptera, Cosmopterigidae)
First occurrence in ores of tetragonal chalcocite
Effects of trace element nutrition on sleep patterns in adult women
N.Z. range management guidelines. 2. Design of grazing management systems for tussock country
A case of lipoma of the esophagus
A revision of world Acanthosomatidae (Heteroptera: Pentatomidae): keys to and descriptions of subfamilies, tribes and genera, with designation of types
Life history of the coronate scyphozoan Linuche unguiculata (Swartz, 1788)
Perceptual restoration of obliterated sounds
Mutagenicity studies on two chromium(III) coordination compounds
The formation of the skeleton. I. Growth of a long bone. 1st appearance of a center of calcification
Leucopenia and abnormal liver function in travellers on malaria chemoprophylaxis
The joint commission: four key root causes loom large in sentinel event data
Treatment of vitiligo with topical 15% lactic acid solution in combination with ultra violet-A
Behaviour of dairy cows within three hours after feed supply: I. Influence of housing type and time elapsing after feed supply
Observations of the propagation velocity and formation mechanism of burst fractures caused by gunshot
Management and control of patients with type 2 diabetes mellitus in Lebanon: results from the International Diabetes Management Practices Study (IDMPS)
The diet composition and nutritional knowledge of patients with anorexia nervosa
Physoporella croatica Herak, 1958 of the Slovak karst Anisian (Slovakia, the West Carpathians Mts.)
Bright lights, big noise. How effective are vehicle warning systems?
Ein Plesiosaurier-Rest mit Magensteinen aus mittlerem Lias von Quedlinburg
Incidence of Chlamydia trachomatis in patients with sterility
Monster soup: the microscope and Victorian fantasy
Preliminary tests with residual sprays against poultry lice
Duration of the life of plants in phylogeny

Up-regulation of endothelin-1 and endothelin type A receptor genes expression in the heart of broiler chickens versus layer chickens


Up-regulation of endothelin-1 and endothelin type A receptor genes expression in the heart of broiler chickens versus layer chickens



Research in Veterinary Science 89(3): 352-357



ISSN/ISBN: 0034-5288

PMID: 20457459

DOI: 10.1016/j.rvsc.2010.04.005

To compare Endothelin (ET) production and genes expression of ET-1 and ET(A) receptor (ET(A)R) between broiler and layer chickens during rearing, semi-quantitative RT-PCR and enzyme immunometric assay were performed in the heart ventricles and serum. There were gradual elevations of ET-1 and ET(A)R mRNAs in the left ventricle of broiler and layer chicken groups that were mainly significant (P<0.05) at 28, 35 and 42 days of age with compared to previous days whereas were not significant between two groups. These gradual elevations of ET-1 and ET(A)R mRNAs were also observed in the right ventricle that were significant (P<0.05) at 28, 35 and 42 days of age in broilers and 42 days of age in layers with compared to previous days. Increasing of these mRNAs in the right ventricle of broiler chickens were significantly (P<0.05) more than layer chickens at 28, 35 and 42 days. Serum ET in broilers was significantly (P<0.05) higher than layer chickens at 28 and 42 days of age. It is concluded that circulating ET and cardiac ET-1, ET(A)R genes expression is higher in broiler chickens than in layer chickens particularly after 21 days of age. It is probably that these breed differences make broiler chickens to be more susceptible to Endothelin related-cardiomyopathies such as congestive heart failure and ascites.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 056773829

Download citation: RISBibTeXText

Related references

Gene expression of endothelin-1 and its receptors in the heart of broiler chickens with T(3)-induced pulmonary hypertension. Research in Veterinary Science 91(3): 370-375, 2011

Endothelin 1, its endothelin type A receptor, connective tissue growth factor, platelet-derived growth factor, and adrenomedullin expression in lungs of pulmonary hypertensive and nonhypertensive chickens. Poultry Science 86(5): 909-916, 2007

Expression of endothelin-1, endothelin-3, endothelin-converting enzyme-1, and endothelin-A and endothelin-B receptor mRNA after angioplasty-induced neointimal formation in the rat. Circulation Research 78(2): 322-328, 1996

Plasma endothelin-1 and single nucleotide polymorphisms of endothelin-1 and endothelin type A receptor genes as risk factors for normal tension glaucoma. Molecular Vision 22: 1256-1266, 2016

Expression of endothelin-1 and its receptors in the lungs of broiler chickens exposed to high-altitude hypoxia. Avian Pathology: Journal of the W.V.P.A 42(5): 416-419, 2013

Relaxin, a pregnancy hormone, is a functional endothelin-1 antagonist: attenuation of endothelin-1-mediated vasoconstriction by stimulation of endothelin type-B receptor expression via ERK-1/2 and nuclear factor-kappaB. Circulation Research 92(1): 32-40, 2003

Fasting influences steroidogenesis, vascular endothelial growth factor (VEGF) levels and mRNAs expression for VEGF, VEGF receptor type 2 (VEGFR-2), endothelin-1 (ET-1), endothelin receptor type A (ET-A) and endothelin converting enzyme-1 (ECE-1) in newly formed pig corpora lutea. Domestic Animal Endocrinology 28(3): 272-284, 2005

Pulmonary hypertension caused by congestive heart failure is ameliorated by long-term application of an endothelin receptor antagonist. Increased expression of endothelin-1 messenger ribonucleic acid and endothelin-1-like immunoreactivity in the lung in congestive heart failure in rats. Journal of the American College of Cardiology 28(6): 1580-1588, 1996

The endothelin ETB receptor acts as a clearance receptor for circulating endothelin-1 in patients with chronic heart failure Implications of anti-endothelin therapy. European Heart Journal 19(ABST Suppl ): 354, 1998

Endothelin-1 increases CHSY-1 expression in aortic endothelial cells via transactivation of transforming growth factor β type I receptor induced by type B receptor endothelin-1. Journal of Pharmacy and Pharmacology 71(6): 988-995, 2019

Role of endothelin in deterioration of heart failure due to cardiomyopathy in hamsters : Increase in endothelin-1 production in the heart and beneficial effect of endothelin-A receptor antagonist on survival and cardiac function. Circulation 99(16): 2171-2176, 1999

Role of endothelin in deterioration of heart failure due to cardiomyopathy in hamsters: increase in endothelin-1 production in the heart and beneficial effect of endothelin-A receptor antagonist on survival and cardiac function. Circulation 99(16): 2171-2176, 1999

Up-regulation of endothelin type a receptor in human and rat radiation proctitis: preclinical therapeutic approach with endothelin receptor blockade. International Journal of Radiation Oncology Biology Physics 74(2): 528-538, 2009

Correlation between endothelin-1, endothelin-A- and endothelin-B-receptor expression, VEGF expression and angiogenesis in breast cancer High throughput tissue microarray analysis. Breast Cancer Research and Treatment 82(Suppl 1): S135-S136, 2003

Endothelin-1-, endothelin-A-, and endothelin-B-receptor expression is correlated with vascular endothelial growth factor expression and angiogenesis in breast cancer. Clinical Cancer Research: An Official Journal of the American Association for Cancer Research 10(7): 2393-2400, 2004