+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Urothelial dysfunction and chronic inflammation in patients with spinal cord injuries at different levels and correlation with urodynamic findings



Urothelial dysfunction and chronic inflammation in patients with spinal cord injuries at different levels and correlation with urodynamic findings



Neurourology and Urodynamics 34(8): 757-762



To investigate urothelial dysfunction and suburothelial inflammation in patients with chronic SCI at different spinal cord levels. Immunofluorescence staining of E-cadherin, zonula occludens-1 (ZO-1), tryptase (mast cell activation), and apoptosis tests on bladder biopsy specimens including urothelium and suburothelium were performed in 34 chronic SCI patients and 10 controls. Video-urodynamic studies were also analyzed and correlated with immunofluorescence findings. The mean interval from SCI to bladder biopsy was 9.3 ± 8.4 years. Patients with chronic SCI had significantly lower expression of E-cadherin (20.86 ± 14.07 vs. 42.40 ± 16.73, the fluorescence intensity per 4 µm(2)) and ZO-1 (5.54 ± 3.73 vs. 11.01 ± 5.66, the fluorescence intensity per 4 µm(2)) than controls (both P < 0.05). Additionally, suburothelial activated mast cells (16.60 ± 6.85 vs. 1.25 ± 1.15, positive cells per 100 cells) and apoptotic cell numbers (5.39 ± 4.86 vs. 0.08 ± 0.26, positive cells per 100 cells) were significantly higher than in controls (both P < 0.05). Immunofluorescence characteristics and video-urodynamic findings did not differ between patients with 15 cervical and 19 thoracic SCIs. Suburothelial activated mast cell numbers correlated negatively to E-cadherin expression in the urothelium (r = -0.559, P < 0.05). Additionally, apoptotic cell number correlated negatively with cystometric bladder capacity (r = -0.535, P < 0.05). Decreased expression of urothelial adhesion and junction proteins and increased suburothelial inflammation and apoptosis were found in patients with chronic SCI, regardless of injury level. Such mechanisms might contribute to the vulnerability of patients with SCI to cystitis and recurrent bacterial infections.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 056788902

Download citation: RISBibTeXText

PMID: 25065363

DOI: 10.1002/nau.22650


Related references

A comparison of urodynamic findings between patients with complete and incomplete traumatic spinal cord injuries. Journal of Spinal Cord Medicine 2018: 1-6, 2018

Clinical correlation of urodynamic findings in patients with localized partial lesions of the spinal cord and cauda equina. Surgical Neurology 21(2): 148-154, 1984

Neurogenic lower urinary tract dysfunction (NLUTD) in patients with spinal cord injury: long-term urodynamic findings. Bju International 115(Suppl. 6): 33-38, 2015

Extracorporeal Shock Wave Lithotripsy Monotherapy for Renal Calculi in Patients With Spinal Cord Injury Correlation of Its Outcome With Urodynamic Findings. Journal of Endourology 8(Suppl. 1): S130, 1994

Urodynamic and rectomanometric findings in patients with spinal cord injury. Neurourology and Urodynamics 20(1): 95-103, 2001

Reproducibility of urodynamic tests in patients with spinal cord injuries and indwelling catheters. Presse Medicale 25(2): 85, 1996

Comparison of Autonomic Reactions during Urodynamic Examination in Patients with Spinal Cord Injuries and Able-Bodied Subjects. Plos one 11(8): E0161976, 2016

Association between the bladder wall thickness and urodynamic findings in patients with spinal cord injury. World Journal of Urology 33(1): 131-135, 2015

Comparison of urodynamic findings in patients with upper and lower cervical spinal cord injury. Spinal Cord 51(10): 780-783, 2013

Significance of urodynamic examination in patients with spinal cord lesions and verified neurogenic urination dysfunction. Medical Archives 67(4): 292-294, 2013

Correlation between clinical neurological data and urodynamic function in spinal cord injured patients. Spinal Cord. 35(4): 213-216, 1997

Voiding dysfunction and urodynamic findings in patients with lumbar spinal stenosis and the effect of decompressive laminectomy. Scandinavian Journal of Urology and Nephrology 29(2): 167-171, 1995

Voiding dysfunction and urodynamic findings in patients with cervical spondylotic spinal stenosis compared with severity of the disease. British Journal of Urology 70(2): 144-148, 1992

Urothelial Dysfunction and Chronic Inflammation are Associated With Increased Bladder Sensation in Patients With Chronic Renal Insufficiency. International Neurourology Journal 22(Suppl 1): S46, 2018

Clinical Efficacy and Changes of Urothelial Dysfunction after Repeated Detrusor Botulinum Toxin A Injections in Chronic Spinal Cord-Injured Bladder. Toxins 8(6):, 2016