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Use of thiolated oligonucleotides as anti-fouling diluents in electrochemical peptide-based sensors



Use of thiolated oligonucleotides as anti-fouling diluents in electrochemical peptide-based sensors



Chemical Communications 50(36): 4690-4692



We incorporated short thiolated oligonucleotides as passivating diluents in the fabrication of electrochemical peptide-based (E-PB) sensors, with the goal of creating a negatively charged layer capable of resisting non-specific adsorption of matrix contaminants. The E-PB HIV sensors fabricated using these diluents were found to be more specific and selective, while retaining attributes similar to the sensor fabricated without these diluents. Overall, these results highlight the advantages of using oligonucleotides as anti-fouling diluents in self-assembled monolayer-based sensors.

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Accession: 056805899

Download citation: RISBibTeXText

PMID: 24668223

DOI: 10.1039/c4cc01290a


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