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Volumetric MRI analysis of hippocampal subregions in Cushing's disease: a model for glucocorticoid neural modulation



Volumetric MRI analysis of hippocampal subregions in Cushing's disease: a model for glucocorticoid neural modulation



European Psychiatry 26(1): 64-67



Several preclinical studies have demonstrated neuronal effects of glucocorticoids on the hippocampus (HC), a limbic structure with anterior-posterior anatomical and functional segmentation. We propose a volumetric magnetic resonance imaging analysis of hippocampus head (HH), body (HB) and tail (HT) using Cushing's disease (CD) as model, to investigate whether there is a differential sensitivity to glucocorticoid neuronal damage in these segments. We found a significant difference in the HH bilaterally after 12 months from trans-sphenoidal surgical selective resection of the adrenocorticotropic hormone (ACTH)-secreting pituitary micro-adenomas. This pre-post surgery difference could contribute to better understand the pathopysiology of CD as an in vivo model for stress-related hypercortisolemic neuropsychiatric disorders.

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Accession: 056892911

Download citation: RISBibTeXText

PMID: 21067899

DOI: 10.1016/j.eurpsy.2010.09.003


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