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WHO HIV clinical staging or CD4 cell counts for antiretroviral therapy eligibility assessment? An evaluation in rural Rakai district, Uganda

Kagaayi, J.; Makumbi, F.; Nakigozi, G.; Wawer, M.J.; Gray, R.H.; Serwadda, D.; Reynolds, S.J.

Aids 21(9): 1208-1210

2007


ISSN/ISBN: 0269-9370
PMID: 17502733
DOI: 10.1097/qad.0b013e32810c8dce
Accession: 056896271

The ability of WHO clinical staging to predict CD4 cell counts of 200 cells/microl or less was evaluated among 1221 patients screened for antiretroviral therapy (ART). Sensitivity was 51% and specificity was 88%. The positive predictive value was 64% and the negative predictive value was 81%. Clinical criteria missed half the patients with CD4 cell counts of 200 cells/microl or less, highlighting the importance of CD4 cell measurements for the scale-up of ART provision in resource-limited settings.

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