Withanolide artifacts formed in methanol
Cao, C.-M.; Zhang, H.; Gallagher, R.J.; Timmermann, B.N.
Journal of Natural Products 76(11): 2040-2046
ISSN/ISBN: 1520-6025 PMID: 24152046 DOI: 10.1021/np400296s
Methanol solutions of the main withanolides (6-8) naturally present in Physalis longifolia yielded five artificial withanolides (1-5), including three new compounds (1-3). Withanolides 1 and 2 were identified as intramolecular Michael addition derivatives, while withanolides 3-5 were the result of intermolecular Michael addition. A comprehensive literature investigation was conducted to identify potential withanolide Michael addition artifacts isolated from Solanaceous species to date.