+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Xanthones from Polygala karensium inhibit neuraminidases from influenza A viruses

Xanthones from Polygala karensium inhibit neuraminidases from influenza A viruses

Bioorganic and Medicinal Chemistry Letters 22(11): 3688-3692

The emergence of the H1N1 swine flu pandemic has the possibility to develop the occurrence of disaster- or drug-resistant viruses by additional reassortments in novel influenza A virus. In the course of an anti-influenza screening program for natural products, 10 xanthone derivatives (1-10) were isolated by bioassay-guided fractionation from the EtOAc-soluble extract of Polygala karensium. Compounds 1, 3, 5, 7, and 9 with a hydroxy group at C-1 showed strong inhibitory effects on neuraminidases from various influenza viral strains, H1N1, H9N2, novel H1N1 (WT), and oseltamivir-resistant novel H1N1 (H274Y) expressed in 293T cells. In addition, these compounds reduced the cytopathic effect of H1N1 swine influenza virus in MDCK cells. Our results suggest that xanthones from P. karensium may be useful in the prevention and treatment of disease by influenza viruses.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 056968927

Download citation: RISBibTeXText

PMID: 22552195

DOI: 10.1016/j.bmcl.2012.04.028

Related references

Quantitative determination of nine xanthones in Polygala caudata and fingerprinting of Polygala L. by HPLC. Journal of Liquid Chromatography and Related Technologies 28(18): 2953-2963, 2005

Extractives of polygala part 5 new tri oxygenated xanthones of polygala arillata. Journal of the Chemical Society Perkin Transactions I (7): 740-743, 1977

Extractives of Polygala. 5. New trioxygenated xanthones of Polygala arillata. 1977

Serological relationships between the neuraminidases in influenza viruses. Journal of General Virology 2(3): 385-394, 1968

Antigenic characteristics of neuraminidases from duck influenza viruses. Sel' skokhozyaistvennaya Biologiya 9(1): 138-140, 1974

Separation and purification of hemagglutinins and neuraminidases of influenza A viruses. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae 4(1): 24-27, 1982

Influenza A2 neuraminidases and their changes during persistance of viruses in tissue cultures. Zeitschrift für die Gesamte Hygiene und Ihre Grenzgebiete 21(4): 324-329, 1975

The reaction of influenza viruses with guinea pig poly-morphonuclear leucocytes III Studies on the mechanism by which influenza viruses inhibit phagocytosis1. Virology: 656-664, 1956

Physiochemical properties of purified and virion neuraminidases of the influenza B viruses. Voprosy Virusologii 32(2): 156-159, 1987

Immunological relationships between the neuraminidases of human and animal influenza viruses. Bulletin of the World Health Organization 41(3): 437-445, 1969

An investigation of antigenic drift of neuraminidases of influenza A (H1N1) viruses. Journal of Hygiene 92(2): 223-229, 1984

Evolutionary dynamics of the N1 neuraminidases of the main lineages of influenza A viruses. Molecular Phylogenetics and Evolution 56(2): 526-535, 2010

Antigenic relations between neuraminidases N 1 of human influenza viruses type A. Virologie 32(2): 115-121, 1981