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Yos9, a control protein for misfolded glycosylated and non-glycosylated proteins in ERAD

Benitez, E.M.; Stolz, A.; Wolf, D.H.

Febs Letters 585(19): 3015-3019

2011


ISSN/ISBN: 1873-3468
PMID: 21871892
DOI: 10.1016/j.febslet.2011.08.021
Accession: 056972879

The endoplasmic reticulum (ER) is responsible for folding and delivery of secretory proteins to their site of action. One major modification proteins undergo in this organelle is N-glycosylation. Proteins that cannot fold properly will be directed to a process known as endoplasmic reticulum associated degradation (ERAD). Processing of N-glycans generates a signal for ERAD. The lectin Yos9 recognizes the N-glycan signal of misfolded proteins and acts as a gatekeeper for the delivery of these substrates to the cytoplasm for degradation. Presence of Yos9 accelerates degradation of the glycosylated model ERAD substrate CPY∗. Here we show that Yos9 has also a control function in degradation of the unglycosylated ERAD substrate CPY∗0000. It decelerates its degradation rate.

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