+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

A Clinical, Biological, and Biomaterials Perspective into Tendon Injuries and Regeneration

A Clinical, Biological, and Biomaterials Perspective into Tendon Injuries and Regeneration

Tissue Engineering. Part B, Reviews 23(1): 44-58

Tendon injury is common and debilitating, and it is associated with long-term pain and ineffective healing. It is estimated to afflict 25% of the adult population and is often a career-ending disease in athletes and racehorses. Tendon injury is associated with high morbidity, pain, and long-term suffering for the patient. Due to the low cellularity and vascularity of tendon tissue, once damage has occurred, the repair process is slow and inefficient, resulting in mechanically, structurally, and functionally inferior tissue. Current treatment options focus on pain management, often being palliative and temporary and ending in reduced function. Most treatments available do not address the underlying cause of the disease and, as such, are often ineffective with variable results. The need for an advanced therapeutic that addresses the underlying pathology is evident. Tissue engineering and regenerative medicine is an emerging field that is aimed at stimulating the body's own repair system to produce de novo tissue through the use of factors such as cells, proteins, and genes that are delivered by a biomaterial scaffold. Successful tissue engineering strategies for tendon regeneration should be built on a foundation of understanding of the molecular and cellular composition of healthy compared with damaged tendon, and the inherent differences seen in the tissue after disease. This article presents a comprehensive clinical, biological, and biomaterials insight into tendon tissue engineering and regeneration toward more advanced therapeutics.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 057023472

Download citation: RISBibTeXText

PMID: 27596929

DOI: 10.1089/ten.TEB.2016.0181

Related references

Regeneration and repair of tendon and ligament tissue using collagen fibre biomaterials. Acta Biomaterialia 7(9): 3237-3247, 2012

Novel strategies in tendon and ligament tissue engineering: Advanced biomaterials and regeneration motifs. Sports Medicine, Arthroscopy, Rehabilitation, Therapy & Technology 2: 20-20, 2010

Biomechanical Stability of Dental Implants in Augmented Maxillary Sites: Results of a Randomized Clinical Study with Four Different Biomaterials and PRF and a Biological View on Guided Bone Regeneration. Biomed Research International 2015(): 850340-850340, 2016

Clinical analysis of treating 164 cases of tendon and ligament injuries with allograft tendon. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 23(6): 666-669, 2010

Magnesium biomaterials for orthopedic application: a review from a biological perspective. Journal of Biomedical Materials Research. Part B, Applied Biomaterials 102(6): 1316-1331, 2015

Treatment of flexor tendon injuries: surgeons' perspective. Journal of Hand Therapy 12(2): 141-148, 1999

Achilles and peroneal tendon injuries in the athlete. An expert's perspective. Clinics in Podiatric Medicine and Surgery 14(3): 447-458, 1997

The differential effects of leukocyte-containing and pure platelet-rich plasma (PRP) on tendon stem/progenitor cells - implications of PRP application for the clinical treatment of tendon injuries. Stem Cell Research & Therapy 6(): 173-173, 2016

Ultrastructural changes of human skeletal muscle after tendon and nerve injuries part 1 fine structural changes of the hand muscles after tendon injuries. Archiv fuer Orthopaedische und Unfall-Chirurgie 84(2): 179-186, 1976

Marine-derived biological macromolecule-based biomaterials for wound healing and skin tissue regeneration. International Journal of Biological Macromolecules 77: 24-35, 2016

Clinical results of multilayered biomaterials for osteochondral regeneration. Journal of Experimental Orthopaedics 1(1): 10-10, 2014

Nano-biomaterials for cardiovascular applications: Clinical perspective. Journal of Controlled Release 229: 23-36, 2017

A biological study establishing the endotoxin limit of biomaterials for bone regeneration in cranial and femoral implantation of rats. Journal of Biomedical Materials Research. Part B, Applied Biomaterials 105(6): 1514-1524, 2016

Studies on regeneration and adhesion of the tendon. Part 7: Influence of the vincula on regeneration of the tendon. Nihon Seikeigeka Gakkai Zasshi 54(12): 1707-1717, 1980

Biological requirements for biomaterials. I. Cytotoxicity of biomaterials, in vitro. II. Cell adhesion to biomaterials, in vitro. Implantologist 3(2): 41-49, 1985