+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

A case report of spontaneous rupture of intracranial epidermoid cyst with dramatic increase of serum carbohydrate antigen 199: a three-year follow-up study



A case report of spontaneous rupture of intracranial epidermoid cyst with dramatic increase of serum carbohydrate antigen 199: a three-year follow-up study



Bmc Neurology 15: 198



Tumor markers are widely applied in clinical practice, however, few serum markers have been found for intracranial tumors. Herein, we firstly report an intracranial epidermoid cyst case with extremely high level of serum CA 199. Furthermore, the relationship between CA 199 level and intracranial epidermoid cyst was closely followed for a long period. We report a case of 41-year-old man with a history of 2 months' headache and sudden exacerbation for 3 days. Radiology examination suggested multiple lesions spreading along ventricular system. Laboratory tests showed exceeding increase of serum CA 199. The patient underwent craniotomy and continuous lumber drainage. Post-operative pathology proved a ruptured intracranial epidermoid cyst. MRI scans and serum CA 199 were closely followed up for three years. This case suggests an important role of serum CA 199 in the diagnosis and follow-up of intracranial epidermoid cyst. Ruptured intracranial epidermoid cyst should be considered for a sudden onset case with multiple intracranial lesions and dramatically increased serum CA 199.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 057053175

Download citation: RISBibTeXText

PMID: 26458877

DOI: 10.1186/s12883-015-0452-8


Related references

Epidermoid cyst of the spleen with spontaneous rupture and massive hemoperitoneum. Case report. Missouri Medicine 67(2): 106-107, 1970

Spontaneous rupture of intracranial dermoid cyst. Report of a case. La Radiologia Medica 96(6): 624-625, 1998

Primary intracranial epidermoid carcinoma accompanied with epidermoid cyst in the cerebellopontine angle--a case report. No Shinkei Geka. Neurological Surgery 15(8): 851-858, 1987

A case of suspected spontaneous rupture of splenic epidermoid cyst. Nihon Geka Hokan. Archiv für Japanische Chirurgie 50(6): 911-917, 1981

Ruptured epidermoid cyst and haematoma of spleen: a diagnostic clue of high levels of serum carcinoembryonic antigen, carbohydrate antigen 19-9 and Sialyl Lewis x. Digestive and Liver Disease 33(7): 595-599, 2001

Ruptured epidermoid cyst and haematoma of spleen: A diagnostic clue of high levels of serum carcinoembryonic antigen, carbohydrate antigen 19-9 and Sialyl Lewis x. Digestive & Liver Disease 33(7): 595-599, 2001

Intracranial epidermoid cyst: case report. Annali Italiani di Chirurgia 79(6): 445-446, 2009

Diagnosis of Intracranial Epidermoid Rupture by MR Imaging. A Case Report. Neuroradiology Journal 22(4): 391-395, 2009

Case report. Malignant change in an intracranial epidermoid cyst. Journal of Computer Assisted Tomography 5(3): 433-435, 1981

Rupture of an aneurysm into a parasellar epidermoid cyst: case report. Journal of Neurosurgery 55(4): 629-632, 1981

Intracranial dermoid cyst rupture-related brain ischemia: Case report and hemodynamic study. Medicine 96(4): E5631, 2017

Intracranial epidermoid cyst including elements of old hematoma: Case report. Neurologia Medico-Chirurgica 37(11): 861-864, 1997

Malignant intracranial epidermoid cyst. Report of a case with leptomeningeal spread. Archives of Pathology 70: 419-423, 1960

Retroperitoneal bronchogenic cyst resembling an adrenal tumor with high levels of serum carbohydrate antigen 19-9: A case report. Medicine 96(31): E7678, 2017

Early recurrence of an intracranial epidermoid cyst due to low-grade infection: case report. Skull Base 16(2): 109-116, 2006