+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

A magnetic resonance imaging grading system for subarachnoid hemorrhage severity in a rat model



A magnetic resonance imaging grading system for subarachnoid hemorrhage severity in a rat model



Journal of Neuroscience Methods 243: 115-119



The endovascular perforation model of subarachnoid hemorrhage (SAH) has a large variation in outcomes. This may reflect differences in the SAH size. Magnetic resonance imaging (MRI) was performed 24h after endovascular perforation in adult male (n=58) and female (n=58) rats. Rats were divided into five grades according to MRI characteristics: grade 0: no SAH or intraventricular hemorrhage (IVH); grade 1: minimal or thin SAH without IVH; grade 2: minimal or thin SAH with IVH; grade 3: thick SAH without IVH; grade 4: thick SAH with IVH. We investigated whether MRI grading scale reflected severity of SAH (determined post mortem) and neurological score. There was a strong correlation between MRI grading scale and current SAH grading scale (P<0.01) and neurological score (P<0.01) in male rats. In female rats, there was also a strong correlation between MRI grading scale and SAH grading scale (P<0.01) but not with neurological score (P=0.24). The current grading system is based on the amount of SAH and needs animal euthanasia to evaluate SAH severity. There is no useful grading system to classify severity of SAH without decapitating animals. We demonstrated a correlation between the MRI grading scale and the current SAH grading scale in an endovascular perforation rat model. The MRI grading scale allows evaluation of SAH severity without euthanizing animals.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 057068504

Download citation: RISBibTeXText

PMID: 25677406

DOI: 10.1016/j.jneumeth.2015.01.035


Related references

New grading system based on magnetic resonance imaging in a mouse model of subarachnoid hemorrhage. Stroke 46(2): 582-584, 2015

Value of Three-Dimensional Maximum Intensity Projection Display to Assist in Magnetic Resonance Imaging (MRI)-Based Grading in a Mouse Model of Subarachnoid Hemorrhage. Medical Science Monitor 22: 2050-2055, 2016

Magnetic resonance imaging detects and predicts early brain injury after subarachnoid hemorrhage in a canine experimental model. Journal of Neurotrauma 25(9): 1099-1106, 2008

Magnetic resonance imaging of subarachnoid hemorrhage. Rofo 176(4): 500-505, 2004

Magnetic resonance imaging of aneurysmal subarachnoid hemorrhage. Nihon Igaku Hoshasen Gakkai Zasshi. Nippon Acta Radiologica 51(11): 1324-1332, 1991

Magnetic resonance imaging of acute subarachnoid hemorrhage. Journal of Neurosurgery 68(5): 731-736, 1988

Detection of hyperacute subarachnoid hemorrhage of the brain by using magnetic resonance imaging. Journal of Neurosurgery 96(4): 684-689, 2002

Diffusion-weighted magnetic resonance imaging in patients with subarachnoid hemorrhage. Neurosurgery 50(4): 741-7; Discussion 747-8, 2002

Magnetic resonance imaging of subarachnoid hemorrhage due to ruptured intracranial aneurysm. No to Shinkei 42(6): 583-590, 1990

A new grading system evaluating bleeding scale in filament perforation subarachnoid hemorrhage rat model. Journal of Neuroscience Methods 167(2): 327-334, 2008

Magnetic resonance imaging with aneurysmal subarachnoid hemorrhage: comparison with computed tomography scan. Surgical Neurology 34(2): 71-78, 1990

Late magnetic resonance imaging related to neurobehavioral functioning after aneurysmal subarachnoid hemorrhage. Neurosurgery 25(3): 390-6; Discussion 396-7, 1989

Diagnostic value of magnetic resonance imaging in perimesencephalic and nonperimesencephalic subarachnoid hemorrhage of unknown origin. Journal of Neurosurgery 114(4): 1003-1007, 2011

Vertebral artery hypoplasia: prevalence and reliability of identifying and grading its severity on magnetic resonance imaging scans. Journal of Manipulative and Physiological Therapeutics 33(3): 207-211, 2010

Subarachnoid hemorrhage in sickle cell anemia: evaluation using parenchymal and vascular magnetic resonance imaging. Neurology 41(9): 1521-1522, 1991