+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

A meta-analysis of low tidal volume on the outcome of adult patients without acute respiratory distress syndrome



A meta-analysis of low tidal volume on the outcome of adult patients without acute respiratory distress syndrome



Zhonghua Nei Ke Za Zhi 55(10): 784-790



Objective: To evaluate the effects of tidal volume on the survival in adult patients without acute respiratory distress syndrome (non-ARDS). Methods: We searched relevant clinical randomized controlled trials (RCT) from January 2000 to December 2015. Meta analyses related to the effects of tidal volume on mortality in non-ARDS adults were conducted using the methods recommended by the Cochrane Collaboration. Results: A total of nineteen RCTs (n=1 679) were finally included. There were 838 patients ventilated with low tidal volume, and the other 841 patients ventilated with normal tidal volume. The mortality rates were not significantly different between low tidal volume group and control group (5.87% vs 6.52%; RR=0.9, P=0.58). But respiratory complications were significantly lower in low tidal volume group, such as development of acute respiratory distress syndrome(RR=0.32, 95% CI 0.16-0.63, P=0.001), pneumonia (RR=0.48, 95%CI 0.29-0.78, P=0.003), while the incidence of atelectasis was quite comparable between two groups (RR=0.78, 95%CI 0.391-1.356, P=0.48). Conclusion: Non-ARDS patients ventilated with low tidal volume is associated with a lower risk of pulmonary complications, yet clinical outcome, mainly mortality is similar to that of patients with regular tidal volume.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 057069353

Download citation: RISBibTeXText

PMID: 27686440


Related references

Low Tidal Volume versus Non-Volume-Limited Strategies for Patients with Acute Respiratory Distress Syndrome. A Systematic Review and Meta-Analysis. Annals of the American Thoracic Society 14(Supplement_4): S271-S279, 2017

The influence of high positive end-expiratory pressure ventilation combined with low tidal volume on prognosis of patients with acute lung injury/acute respiratory distress syndrome: a Meta-analysis. Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 23(1): 5-9, 2011

Association between tidal volume size, duration of ventilation, and sedation needs in patients without acute respiratory distress syndrome: an individual patient data meta-analysis. Intensive Care Medicine 40(7): 950-957, 2014

Prone positioning reduces mortality from acute respiratory distress syndrome in the low tidal volume era: a meta-analysis. Intensive Care Medicine 40(3): 332-341, 2014

High tidal volume decreases adult respiratory distress syndrome, atelectasis, and ventilator days compared with low tidal volume in pediatric burned patients with inhalation injury. Journal of the American College of Surgeons 220(4): 570-578, 2015

Ventilation with lower tidal volumes for critically ill patients without the acute respiratory distress syndrome: a systematic translational review and meta-analysis. Current Opinion in Critical Care 20(1): 25-32, 2014

Association between use of lung-protective ventilation with lower tidal volumes and clinical outcomes among patients without acute respiratory distress syndrome: a meta-analysis. JAMA 308(16): 1651-1659, 2012

Low tidal volume needs to be used in patients with acute respiratory distress syndrome. Critical Care Medicine 33(1): 239-240, 2005

The use of an inflammation-modulating diet in patients with acute lung injury or acute respiratory distress syndrome: a meta-analysis of outcome data. Jpen. Journal of Parenteral and Enteral Nutrition 32(6): 596-605, 2008

Risk of acute lung injury/acute respiratory distress syndrome in critically ill adult patients with pre-existing diabetes: a meta-analysis. Plos one 9(2): E90426, 2014

Shunt adjusted tidal volume predicts barotrauma in patients with adult respiratory distress syndrome. Chest 106(2 Suppl. ): 64S, 1994

Meta-analysis of acute lung injury and acute respiratory distress syndrome trials testing low tidal volumes. American Journal of Respiratory and Critical Care Medicine 166(11): 1510-1514, 2002

Exogenous pulmonary surfactant for the treatment of adult patients with acute respiratory distress syndrome: results of a meta-analysis. Critical Care 10(2): R41, 2006

Lung Recruitment Maneuvers for Adult Patients with Acute Respiratory Distress Syndrome. A Systematic Review and Meta-Analysis. Annals of the American Thoracic Society 14(Supplement_4): S304-S311, 2017

High-Frequency Oscillation for Adult Patients with Acute Respiratory Distress Syndrome. A Systematic Review and Meta-Analysis. Annals of the American Thoracic Society 14(Supplement_4): S289-S296, 2017