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A mitochondria-targeted fluorescent probe for ratiometric detection of endogenous sulfur dioxide derivatives in cancer cells

Li, D.-P.; Wang, Z.-Y.; Cao, X.-J.; Cui, J.; Wang, X.; Cui, H.-Z.; Miao, J.-Y.; Zhao, B.-X.

Chemical Communications 52(13): 2760-2763

2016


ISSN/ISBN: 1364-548X
PMID: 26757700
DOI: 10.1039/c5cc09092j
Accession: 057070602

A new mitochondria-targeted fluorescent probe HCy-D, constructed by dansyl and hemicyanine fluorophores, for SO2 derivatives (HSO3(-)/SO3(2-)) was presented. This probe was designed based on a new FRET platform. HCy-D showed a ratiometric, sensitive and rapid response to HSO3(-)/SO3(2-). Importantly, HCy-D was successfully used for fluorescence imaging of endogenous bisulfite in HepG2 cells, which may benefit cancer diagnosis by discriminating liver cancer cells from normal liver cells.

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