+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

A molecular arms race between host innate antiviral response and emerging human coronaviruses



A molecular arms race between host innate antiviral response and emerging human coronaviruses



Virologica Sinica 31(1): 12-23



Coronaviruses have been closely related with mankind for thousands of years. Community-acquired human coronaviruses have long been recognized to cause common cold. However, zoonotic coronaviruses are now becoming more a global concern with the discovery of highly pathogenic severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS) coronaviruses causing severe respiratory diseases. Infections by these emerging human coronaviruses are characterized by less robust interferon production. Treatment of patients with recombinant interferon regimen promises beneficial outcomes, suggesting that compromised interferon expression might contribute at least partially to the severity of disease. The mechanisms by which coronaviruses evade host innate antiviral response are under intense investigations. This review focuses on the fierce arms race between host innate antiviral immunity and emerging human coronaviruses. Particularly, the host pathogen recognition receptors and the signal transduction pathways to mount an effective antiviral response against SARS and MERS coronavirus infection are discussed. On the other hand, the counter-measures evolved by SARS and MERS coronaviruses to circumvent host defense are also dissected. With a better understanding of the dynamic interaction between host and coronaviruses, it is hoped that insights on the pathogenesis of newly-identified highly pathogenic human coronaviruses and new strategies in antiviral development can be derived.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 057071356

Download citation: RISBibTeXText

PMID: 26786772

DOI: 10.1007/s12250-015-3683-3


Related references

Intrinsic disorder in proteins involved in the innate antiviral immunity: another flexible side of a molecular arms race. Journal of Molecular Biology 426(6): 1322-1350, 2014

An arms race: innate antiviral responses and counteracting viral strategies. Biochemical Society Transactions 35(Pt 6): 1512-1514, 2007

Catch me if you can: the arms race between human cytomegalovirus and the innate immune system. Future Virology 14(4): 247-263, 2019

Hosts Are Ahead In A Marine Host-Parasite Coevolutionary Arms Race: Innate Immune System Adaptation In Pipefish Syngnathus Typhie Against Vibrio Phylotypes. Evolution 66(8): 2528-2539, 2012

Hosts are ahead in a marine host-parasite coevolutionary arms race: innate immune system adaptation in pipefish Syngnathus typhle against Vibrio phylotypes. Evolution; International Journal of Organic Evolution 66(8): 2528-2539, 2012

The Class IV human deacetylase, HDAC11, exhibits anti-influenza A virus properties via its involvement in host innate antiviral response. Cellular Microbiology 21(4): E12989, 2019

RNA silencing against viruses molecular arms race between Cucumber mosaic virus and its host. Journal of General Plant Pathology 79(4): 227-232, 2013

Toxoplasma's arms race with the host interferon response: a ménage à trois of ROPs. Cell Host and Microbe 15(5): 517-518, 2014

Evaluation of serologic and antigenic relationships between middle eastern respiratory syndrome coronavirus and other coronaviruses to develop vaccine platforms for the rapid response to emerging coronaviruses. Journal of Infectious Diseases 209(7): 995, 2014

Host-specific response to HCV infection in the chimeric SCID-beige/Alb-uPA mouse model: role of the innate antiviral immune response. Plos Pathogens 2(6): E59, 2006

TLR3 and TLR4 are innate antiviral immune receptors in human microglia: role of IRF3 in modulating antiviral and inflammatory response in the CNS. Virology 392(2): 246-259, 2009

Immune evasion of porcine enteric coronaviruses and viral modulation of antiviral innate signaling. Virus Research 226: 128-141, 2016

RNA helicases: emerging roles in viral replication and the host innate response. Rna Biology 7(6): 775-787, 2011

SAMD9 is an innate antiviral host factor with stress response properties that can be antagonized by poxviruses. Journal of Virology 89(3): 1925-1931, 2015

Chronic hepatitis C virus infection attenuates host antiviral innate immune response. Nihon Rinsho. Japanese Journal of Clinical Medicine 73(2): 234-238, 2015