+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

A neural model of normal and abnormal learning and memory consolidation: adaptively timed conditioning, hippocampus, amnesia, neurotrophins, and consciousness

A neural model of normal and abnormal learning and memory consolidation: adaptively timed conditioning, hippocampus, amnesia, neurotrophins, and consciousness

Cognitive Affective and Behavioral Neuroscience 17(1): 24-76

How do the hippocampus and amygdala interact with thalamocortical systems to regulate cognitive and cognitive-emotional learning? Why do lesions of thalamus, amygdala, hippocampus, and cortex have differential effects depending on the phase of learning when they occur? In particular, why is the hippocampus typically needed for trace conditioning, but not delay conditioning, and what do the exceptions reveal? Why do amygdala lesions made before or immediately after training decelerate conditioning while those made later do not? Why do thalamic or sensory cortical lesions degrade trace conditioning more than delay conditioning? Why do hippocampal lesions during trace conditioning experiments degrade recent but not temporally remote learning? Why do orbitofrontal cortical lesions degrade temporally remote but not recent or post-lesion learning? How is temporally graded amnesia caused by ablation of prefrontal cortex after memory consolidation? How are attention and consciousness linked during conditioning? How do neurotrophins, notably brain-derived neurotrophic factor (BDNF), influence memory formation and consolidation? Is there a common output path for learned performance? A neural model proposes a unified answer to these questions that overcome problems of alternative memory models.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 057073521

Download citation: RISBibTeXText

PMID: 27905080

DOI: 10.3758/s13415-016-0463-y

Related references

A neural network model of adaptively timed reinforcement learning and hippocampal dynamics. Brain Research. Cognitive Brain Research 1(1): 3-38, 1992

Neural dynamics of category learning and recognition attention memory consolidation and amnesia. Davis, J L , R W Newburgh And E J Wegman (Ed ) Aaas (American Association For The Advancement Of Science) Selected Symposium, Vol 105 Brain Structure, Learning, And Memory; Meeting, May 1984, New York, New York, Usa Xvi+301p Westview Press, Inc : Boulder, Colorado, Usa; American Association For The Advancement Of Science: Washington, D C , Usa Illus Paper 233-290, 1988

The hippocampus and cerebellum in adaptively timed learning, recognition, and movement. Journal of Cognitive Neuroscience 8(3): 257-277, 1996

New neural multiprocess memory model for adaptively regulating associative learning. Neural Networks 7(9): 1351-1378, 1994

The Conscious Brain: Abnormal and Normal || The Neural Correlates of Consciousness: An Analysis of Cognitive Skill Learning. Philosophical Transactions Biological Sciences 353(1377): 1889-1901, 1998

Acetylcholine Neuromodulation in Normal and Abnormal Learning and Memory: Vigilance Control in Waking, Sleep, Autism, Amnesia and Alzheimer's Disease. Frontiers in Neural Circuits 11: 82, 2017

Neural Dynamics of Autistic Repetitive Behaviors and Fragile X Syndrome: Basal Ganglia Movement Gating and mGluR-Modulated Adaptively Timed Learning. Frontiers in Psychology 9: 269, 2018

Sequential learning during contextual fear conditioning guides the rate of systems consolidation: Implications for consolidation of multiple memory traces. Hippocampus 27(5): 518-528, 2017

Neural dynamics of category learning and recognition attention consolidation amnesia. Bulletin of the Psychonomic Society 23(4): 293, 1985

Dense retrograde amnesia, intact learning capability and abnormal forgetting rate: a consolidation deficit?. Cortex 29(3): 449-466, 1993

HSP70 Facilitates Memory Consolidation of Fear Conditioning through MAPK Pathway in the Hippocampus. Neuroscience 375: 108-118, 2018

Tracelink: A model of amnesia and consolidation of memory. Hippocampus 6(6): 675-684, 1996

Hippocampus and retrograde amnesia in the rat model: a modest proposal for the situation of systems consolidation. Neuropsychologia 48(8): 2357-2369, 2010

Consolidation Of The Neural Trace In Memory: Investigation With One-Trial Avoidance Conditioning And Ecs. Journal of Comparative and Physiological Psychology 59: 283-284, 1965

New learning and remote memory in the same and different domains of experience: implications for normal memory and amnesia. Cortex 36(2): 195-211, 2000